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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

文献类型：期刊论文

作者Jiang, Jue9,10,11; Wang, Jingchao9,10,11; Yue, Ming8,11; Cai, Xiaolian7; Wang, Tianci9; Wu, Chao9; Su, Hexiu9; Wang, Yanwu6; Han, Meng5; Zhang, Yingchi2,3,4
刊名CANCER CELL
出版日期2020-02-10
卷号37期号:2页码:200-+
ISSN号1535-6108
DOI10.1016/j.ccell.2020.01.001
通讯作者Liu, Hudan(hudanliu@whu.edu.cn)
英文摘要Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive. Herein, we identify a molecular mechanism responsible for reciprocal activation between Aurora B kinase (AURKB) and MYC. AURKB directly phosphorylates MYC at serine 67, counteracting GSK3b-directed threonine 58 phosphorylation and subsequent FBXW7-mediated proteasomal degradation. Stabilized MYC, in concert with T cell acute lymphoblastic leukemia 1 (TAL1), directly activates AURKB transcription, constituting a positive feedforward loop that reinforces MYC-regulated oncogenic programs. Therefore, inhibitors of AURKB induce prominent MYC degradation concomitant with robust leukemia cell death. These findings reveal an AURKB-MYC regulatory circuit that underlies T cell leukemogenesis, and provide a rationale for therapeutic targeting of oncogenic MYC via AURKB inhibition.
WOS关键词C-MYC ; ONCOGENIC TRANSFORMATION ; TUMOR-SUPPRESSOR ; N-MYC ; ACTIVATION ; EXPRESSION ; LEUKEMIA ; PATHWAY ; COMPLEX ; NOTCH1
资助项目National Key R&D Program of China[2017YFA0505600] ; National Natural Science Foundation of China[81970152] ; National Natural Science Foundation of China[81770177] ; National Natural Science Foundation of China[81830084] ; National Natural Science Foundation of China[81803003] ; National Science Foundation for Distinguished Young Scholar[81725013] ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars[2017CFA072] ; Hubei Provincial Natural Science Fund for Creative Research Groups[2018CFA018] ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University[TFJC2018005] ; National Institutes of Health[CA215059] ; American Cancer Society[RSG-17-204-01-TBG]
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000513775300010
出版者CELL PRESS
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; American Cancer Society ; American Cancer Society ; American Cancer Society ; American Cancer Society ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; American Cancer Society ; American Cancer Society ; American Cancer Society ; American Cancer Society ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; American Cancer Society ; American Cancer Society ; American Cancer Society ; American Cancer Society ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; National Science Foundation for Distinguished Young Scholar ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Distinguished Young Scholars ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Hubei Provincial Natural Science Fund for Creative Research Groups ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; National Institutes of Health ; American Cancer Society ; American Cancer Society ; American Cancer Society ; American Cancer Society
源URL[http://ir.ihb.ac.cn/handle/342005/35000]  
专题水生生物研究所_其他_期刊论文
通讯作者Liu, Hudan
作者单位1.Tsinghua Univ, Sch Life Sci, Collaborat Innovat Ctr Canc Med, Beijing 100084, Peoples R China
2.Peking Union Med Coll, Tianjin 300020, Peoples R China
3.Chinese Acad Med Sci, Div Pediat, Blood Dis Ctr, Inst Hematol & Blood Dis Hosp, Tianjin 300020, Peoples R China
4.Chinese Acad Med Sci, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China
5.Tsinghua Univ, Sch Life Sci, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China
6.Wuhan Univ, Sch Basic Med Sci, Dept Histol & Embryol, Wuhan 430071, Peoples R China
7.Chinese Acad Sci, Innovat Acad Seed Design, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
8.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430014, Peoples R China
9.Wuhan Univ, Med Res Inst, Frontier Sci Ctr Immunol & Metab, Wuhan 430071, Peoples R China
10.Wuhan Univ, Zhongnan Hosp, Dept Hematol, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Jue,Wang, Jingchao,Yue, Ming,et al. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis[J]. CANCER CELL,2020,37(2):200-+.
APA Jiang, Jue.,Wang, Jingchao.,Yue, Ming.,Cai, Xiaolian.,Wang, Tianci.,...&Liu, Hudan.(2020).Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.CANCER CELL,37(2),200-+.
MLA Jiang, Jue,et al."Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis".CANCER CELL 37.2(2020):200-+.

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来源：水生生物研究所

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