Molecular Mechanisms of Anticancer Activities of Puerarin
文献类型:期刊论文
作者 | Ahmad, Bashir6; Khan, Suliman2,7; Liu, Yang2,7; Xue, Mengzhou2,7; Nabi, Ghulam4; Kumar, Sunjeet5; Alshwmi, Mohammed1; Qarluq, Abdul Wakeel3 |
刊名 | CANCER MANAGEMENT AND RESEARCH |
出版日期 | 2020 |
卷号 | 12期号:1页码:79-90 |
ISSN号 | 1179-1322 |
关键词 | medicinal plants natural products Puerarin Pueraria lobata Pueraria thomsonii Pueraria tuberosa |
DOI | 10.2147/CMAR.S233567 |
英文摘要 | Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment. |
WOS关键词 | NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; ELEMENT TRANSCRIPTIONAL ACTIVITY ; CANCER CELL-PROLIFERATION ; G2/M PHASE ARREST ; NATURAL-PRODUCTS ; MULTIDRUG-RESISTANCE ; SIGNALING PATHWAYS ; UP-REGULATION ; INTRINSIC APOPTOSIS |
WOS研究方向 | Oncology |
语种 | 英语 |
出版者 | DOVE MEDICAL PRESS LTD |
WOS记录号 | WOS:000506015500001 |
源URL | [http://ir.ihb.ac.cn/handle/342005/35525] |
专题 | 水生生物研究所_其他_期刊论文 |
通讯作者 | Xue, Mengzhou; Nabi, Ghulam |
作者单位 | 1.Dalian Med Univ, Affiliated Hosp 1, Dept Clin Lab, Dalian 116044, Liaoning, Peoples R China 2.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China 3.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Liaoning, Peoples R China 4.Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050024, Hebei, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 6.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol & Pathophysiol, Dalian 116044, Liaoning, Peoples R China 7.Zhengzhou Univ, Dept Cerebrovasc Dis, Affiliated Hosp 2, Zhengzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Ahmad, Bashir,Khan, Suliman,Liu, Yang,et al. Molecular Mechanisms of Anticancer Activities of Puerarin[J]. CANCER MANAGEMENT AND RESEARCH,2020,12(1):79-90. |
APA | Ahmad, Bashir.,Khan, Suliman.,Liu, Yang.,Xue, Mengzhou.,Nabi, Ghulam.,...&Qarluq, Abdul Wakeel.(2020).Molecular Mechanisms of Anticancer Activities of Puerarin.CANCER MANAGEMENT AND RESEARCH,12(1),79-90. |
MLA | Ahmad, Bashir,et al."Molecular Mechanisms of Anticancer Activities of Puerarin".CANCER MANAGEMENT AND RESEARCH 12.1(2020):79-90. |
入库方式: OAI收割
来源:水生生物研究所
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