Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish
文献类型:期刊论文
作者 | Ren, Fan3; Lin, Qiaohong3; Gong, Gaorui3; Du, Xian1,4; Dan, Hong3; Qin, Wenying1,4; Miao, Ran3; Xiong, Yang3; Xiao, Rui1,4; Li, Xiaohui3 |
刊名 | COMMUNICATIONS BIOLOGY |
出版日期 | 2020-03-03 |
卷号 | 3期号:1页码:10 |
DOI | 10.1038/s42003-020-0827-2 |
英文摘要 | Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how the embryos maintain maternal mRNA stability remains unclear. Here, we identify Igf2bp3 as an important regulator of maternal mRNA stability in zebrafish. Depletion of maternal igf2bp3 destabilizes maternal mRNAs prior to MZT and leads to severe developmental defects, including abnormal cytoskeleton organization and cell division. However, the process of oogenesis and the expression levels of maternal mRNAs in unfertilized eggs are normal in maternal igf2bp3 mutants. Gene ontology analysis revealed that these functions are largely mediated by Igf2bp3-bound mRNAs. Indeed, Igf2bp3 depletion destabilizes while its overexpression enhances its targeting maternal mRNAs. Interestingly, igf2bp3 overexpression in wild-type embryos also causes a developmental delay. Altogether, these findings highlight an important function of Igf2bp3 in controlling early zebrafish embryogenesis by binding and regulating the stability of maternal mRNAs. In early embryogenesis, maternal mRNAs are degraded at the maternal-to-zygotic transition (MZT). Mei et al find that the stability of maternal mRNAs before MZT is maintained by the mRNA binding protein Igf2bp3, which is also required for normal zebrafish development. |
WOS关键词 | TO-ZYGOTIC TRANSITION ; FILAMENTOUS ACTIN ; BUCKY BALL ; MYOSIN-II ; GENE ; TRANSCRIPTOME ; CLEARANCE ; CYTOSKELETON ; TRANSLATION ; PACKAGE |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000518989000002 |
源URL | [http://ir.ihb.ac.cn/handle/342005/35821] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Mei, Jie |
作者单位 | 1.Wuhan Univ, Zhongnan Hosp, Dept Hematol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Med Res Inst, Frontier Sci Ctr Immunol & Metab, Wuhan 430071, Peoples R China |
推荐引用方式 GB/T 7714 | Ren, Fan,Lin, Qiaohong,Gong, Gaorui,et al. Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish[J]. COMMUNICATIONS BIOLOGY,2020,3(1):10. |
APA | Ren, Fan.,Lin, Qiaohong.,Gong, Gaorui.,Du, Xian.,Dan, Hong.,...&Mei, Jie.(2020).Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.COMMUNICATIONS BIOLOGY,3(1),10. |
MLA | Ren, Fan,et al."Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish".COMMUNICATIONS BIOLOGY 3.1(2020):10. |
入库方式: OAI收割
来源:水生生物研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。