Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats
文献类型:期刊论文
作者 | Liu, Xinhe1,2; Wang, Ning1,2; Wang, Jinyan1,2; Luo, Fei1,2 |
刊名 | SCIENTIFIC REPORTS |
出版日期 | 2019-12-10 |
卷号 | 9页码:11 |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-019-55168-w |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Time perception is an important ability that is related closely to humans' and animals' daily activities. It can be distorted by various emotional states. In human studies, experimental pain has been shown to prolong the perception of time. However, related animal studies are lacking. In this study, we used a temporal bisection task to investigate how acute inflammatory pain (induced by hind-paw formalin injection) and chronic neuropathic pain [induced by spinal nerve ligation (SNL)] affected time perception in rats. Rats were trained to recognize "short" (1200-ms) and "long" (2400-ms) anchor-duration pure tones and were rewarded for corresponding lever presses. During testing, rats perceived a series of intermediate-duration and anchor-duration pure tones, and selected levers corresponding to the "short" and "long" tones. After formalin injection, rats gave more "long" lever-press responses than after saline injection. The point of subjective equality after formalin injection also increased, suggesting that formalin-induced acute pain extended time perception. In contrast, rats that had undergone SNL gave fewer "long" lever-press responses compared with the sham surgery group. This animal study suggests that formalin-induced pain and neuropathic pain may have different effects on time perception. |
WOS关键词 | INFLAMMATORY PAIN ; NORADRENERGIC MODULATION ; PREFRONTAL CORTEX ; INTERNAL CLOCK ; PERCEPTION ; DEPRESSION ; ATTENTION ; DISCRIMINATION ; MECHANISMS ; BEHAVIOR |
资助项目 | NNSF (National Natural Science Foundation of China)[31671140] ; NNSF[31271092] ; NNSF[31471061] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH 2014G01] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K02] ; CAS/SAFEA International Partnership Program for Creative Research Teams[Y2CX131003] |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000501991200001 |
资助机构 | NNSF (National Natural Science Foundation of China) ; NNSF ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Program for Creative Research Teams |
源URL | [http://ir.psych.ac.cn/handle/311026/30523] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wang, Ning |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Xinhe,Wang, Ning,Wang, Jinyan,et al. Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats[J]. SCIENTIFIC REPORTS,2019,9:11. |
APA | Liu, Xinhe,Wang, Ning,Wang, Jinyan,&Luo, Fei.(2019).Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.SCIENTIFIC REPORTS,9,11. |
MLA | Liu, Xinhe,et al."Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats".SCIENTIFIC REPORTS 9(2019):11. |
入库方式: OAI收割
来源:心理研究所
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