中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder

文献类型：期刊论文

作者Liu, Wanting1,2; Gan, Jun1; Fan, Jie1; Zheng, Hong1; Li, Sihui1; Chan, Raymond C. K.3,4; Tan, Changlian5; Zhu, Xiongzhao1,2
刊名NEUROIMAGE-CLINICAL
出版日期2019
卷号24页码:8
ISSN号2213-1582
关键词Obsessive-compulsive disorder Insight Cortical thickness Surface-based morphometry
DOI10.1016/j.nicl.2019.102037
通讯作者Tan, Changlian(tanchanglian@csu.edu.cn) ; Zhu, Xiongzhao(xiongzhaozhu@csu.edu.cn)
英文摘要Poor insight in obsessive-compulsive disorder (OCD) is associated with several adverse clinical outcomes. However, the neurobiological basis of this insight deficit is not clearly understood. The present study thus aimed to investigate associations of cortical thickness, cortical surface area and subcortical volumes with insight in a sample of drug-naive adults with OCD. Forty-seven OCD patients and 42 healthy controls (HCs) underwent MRI scanning, depression and anxiety assessments. The Brown Assessment of Beliefs Scale (BABS) measured insight levels and patients were divided into two groups: poor insight (OCD-PI; n = 21), and good insight (OCD-GI; n = 26). Cortical thickness and surface area between groups were compared with whole-brain exploratory vertex-by-vertex analyses, while subcortical volumes were compared on a structure-by-structure basis. Partial correlation analyses were then performed to assess associations between regional cortical and subcortical measures and insight levels. OCD-GI and OCD-PI groups displayed partly shared, but also partly distinct brain structural alterations. Strikingly, OCD-PI showed decreased cortical thickness in the left superior frontal gyrus, left anterior cingulate cortex (ACC) and right inferior parietal gyrus, compared to both OCD-GI and HCs. Average cortical thickness extracted from these areas was further negatively correlated with BABS scores in the OCD-PI patients. Our findings suggest that poor insight in patients with OCD may have a neural substrate involving the left medial frontal and the right inferior parietal cortices.
WOS关键词ANTERIOR CINGULATE CORTEX ; INFERIOR PARIETAL LOBULE ; POOR INSIGHT ; COGNITIVE INSIGHT ; SELF-REFLECTION ; CEREBRAL-CORTEX ; SCHIZOPHRENIA ; BRAIN ; ANOSOGNOSIA ; UNAWARENESS
资助项目National Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01] ; Beijing Training Project for the Leading Talents in ST[Z151100000315020] ; Strategic Priority Research Program (B) of the Chinese Academy of Science[XDB02030002]
WOS研究方向Neurosciences & Neurology
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000504663800019
资助机构National Key Technology Research and Development Program of the Ministry of Science and Technology of China ; Beijing Training Project for the Leading Talents in ST ; Strategic Priority Research Program (B) of the Chinese Academy of Science
源URL[http://ir.psych.ac.cn/handle/311026/30598]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Tan, Changlian; Zhu, Xiongzhao
作者单位1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Inst Med Psychol, Changsha, Hunan, Peoples R China
3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Wanting,Gan, Jun,Fan, Jie,et al. Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder[J]. NEUROIMAGE-CLINICAL,2019,24:8.
APA Liu, Wanting.,Gan, Jun.,Fan, Jie.,Zheng, Hong.,Li, Sihui.,...&Zhu, Xiongzhao.(2019).Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder.NEUROIMAGE-CLINICAL,24,8.
MLA Liu, Wanting,et al."Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder".NEUROIMAGE-CLINICAL 24(2019):8.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。