Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice
文献类型:期刊论文
作者 | Wang, Qiong3; Liu, Yingjuan2; Zhang, Jianxu1; Wang, Weiwen4,5 |
刊名 | FRONTIERS IN PSYCHOLOGY |
出版日期 | 2020-01-10 |
卷号 | 10页码:8 |
ISSN号 | 1664-1078 |
关键词 | stress inoculation predator odor exposure active coping corticotropin-releasing factor receptors locus coeruleus dorsal raphe nuclei |
DOI | 10.3389/fpsyg.2019.03028 |
产权排序 | 3 |
文献子类 | article |
英文摘要 | Stress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress inoculation on behaviors in novel predator odor exposure, open field test and forced swimming test (FST), and on the expression of CRF receptors in locus coeruleus (LC) and dorsal raphe nuclei (DRN). The results showed that predator odor stress inoculation increased the active coping of mice under the severe stress environment without changing the stress response to a new predator odor. Meanwhile, in LC, the CRFR1 expression was increased by predator odor stress inoculation. These results suggested that predator odor stress inoculation can be used as an effective training method to improve active response to later severe stress and the function of CRFR1 in LC might be a potential underlying biological mechanism. |
WOS关键词 | STRESS INOCULATION ; EXPOSURE ; NUCLEUS ; ANXIETY ; CONSEQUENCES ; MODEL ; RATS ; CRF |
资助项目 | National Natural Science Foundation of China[31771217] ; National Natural Science Foundation of China[81471122] ; National Natural Science Foundation of China[31900786] ; MOE (Ministry of Education in China) Project of Humanities and Social Sciences[18YJC190022] ; Henan Society Project Planning[2018BTY019] ; University Key Scientific Research Project Plan of Henan Province[19A190005] ; Henan Provincial Department of Education Project of Humanities and Social Sciences[2019-ZZJH-528] ; Henan Education Science 13th Five-Year Plan planning issues[2018-JKGHYB-0008] |
WOS研究方向 | Psychology |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000509278400001 |
资助机构 | National Natural Science Foundation of China ; MOE (Ministry of Education in China) Project of Humanities and Social Sciences ; Henan Society Project Planning ; University Key Scientific Research Project Plan of Henan Province ; Henan Provincial Department of Education Project of Humanities and Social Sciences ; Henan Education Science 13th Five-Year Plan planning issues |
源URL | [http://ir.psych.ac.cn/handle/311026/30652] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Jianxu; Wang, Weiwen |
作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China 2.Nanyang Normal Univ, Sch Life Sci & Technol, Nanyang, Peoples R China 3.Zhengzhou Univ, Sch Educ, Zhengzhou, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Qiong,Liu, Yingjuan,Zhang, Jianxu,et al. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice[J]. FRONTIERS IN PSYCHOLOGY,2020,10:8. |
APA | Wang, Qiong,Liu, Yingjuan,Zhang, Jianxu,&Wang, Weiwen.(2020).Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice.FRONTIERS IN PSYCHOLOGY,10,8. |
MLA | Wang, Qiong,et al."Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice".FRONTIERS IN PSYCHOLOGY 10(2020):8. |
入库方式: OAI收割
来源:心理研究所
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