Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention
文献类型：期刊论文
| 作者 | Liu Wang1,2; Chen Qiao1,2; Li Yong-Hui1,2
|
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 46期号:10页码:941-951 |
| 关键词 | drug-associated memories neurobiological mechanism extinction training memory reconsolidation virtual reality neuromodulation |
| ISSN号 | 1000-3282 |
| DOI | 10.16476/j.pibb.2019.0079 |
| 通讯作者 | Li Yong-Hui(liyonghui@pscy.ac.cn) |
| 英文摘要 | Relapse behavior after long-term abstinence is the key problem of addiction treatment. A major factor to induce relapse is the persistence of maladaptive drug-associated memories. Persistent changes in structure and function of prefrontal cortex-mesolimbic dopamine system caused by chronic drug abusing, lead to the formation of pathological drug-associated memories. This article reviews addiction with a focus on how it can be conceptualised as a disorder of maladaptive memory, considering the neural basis of drug-associated memories during the initial phase, the habituation phase and the maintenance phase of addictive behavior. The present review summarizes the clinical intervention methods of drug-associated memories in recent years including extinction training, extinction in multiple contexts to facilitate extinction and reconsolidation intervention to disrupt drug-associated memories directly, and the application of virtual reality technology and neuromodulation methods in addiction intervention. The intervention methods combined memory reconsolidation with virtual reality technology or neuromodulation methods are prospected to target drug-associated memories, providing new methods and new ideas to treat addiction in future clinical researches. |
| WOS关键词 | DIRECT-CURRENT STIMULATION ; DEEP BRAIN-STIMULATION ; CUE-EXPOSURE THERAPY ; POST-RETRIEVAL EXTINCTION ; MEDIAL PREFRONTAL CORTEX ; COCAINE-SEEKING ; NUCLEUS-ACCUMBENS ; INDUCED REINSTATEMENT ; BASOLATERAL AMYGDALA ; VIRTUAL-REALITY |
| 资助项目 | National Key Research and Development Program of China[2017YFC1310405] ; National Key Research and Development Program of China[2016YFC0800907] ; National Natural Science Foundation of China[U1736124] ; CAS Key Lab of Mental Health |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000492109100001 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/30757]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li Yong-Hui |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Wang,Chen Qiao,Li Yong-Hui. Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(10):941-951. |
| APA | Liu Wang,Chen Qiao,&Li Yong-Hui.(2019).Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(10),941-951. |
| MLA | Liu Wang,et al."Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.10(2019):941-951. |
入库方式： OAI收割
来源：心理研究所
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