Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation
文献类型:期刊论文
作者 | Ma, Longyu1,5; Yue, Lupeng2,3; Zhang, Yuqi1,5; Wang, Yue1,5; Han, Bingxuan1,5; Cui, Shuang1,5; Liu, Feng-Yu1,5; Wan, You1,4,5,6; Yi, Ming1,4,5 |
刊名 | CELL REPORTS |
出版日期 | 2019-11-05 |
卷号 | 29期号:6页码:1579-+ |
ISSN号 | 2211-1247 |
DOI | 10.1016/j.celrep.2019.10.002 |
产权排序 | 3 |
文献子类 | article |
英文摘要 | Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous brain activity and continuous neuroplastic changes of relevant circuits. Activity in the hippocampus-medial prefrontal cortex (mPFC) pathway has been suggested to correlate with spontaneous pain and pain chronicity, but causal evidence is lacking. Here we combine longitudinal in vivo electrophysiological recording with behavioral testing and show that persistent spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex (vCA1-IL) connectivity and hippocampal modulation of IL neuronal activity in rats with peripheral inflammation. Chemo- and optogenetic rescue of vCA1-IL dysfunction relieves spontaneous pain. Circuit-specific overexpression of brain-derived neurotrophic factor (BDNF) in vCA1-IL reverses electrophysiological changes, relieves spontaneous pain, and accelerates overall recovery from inflammatory pain. Our work identifies a neural pathway that specifically correlates with spontaneous pain and supports the significance of using a circuit dynamics-based strategy for more comprehensive understanding of circuitry mechanisms underlying chronic pain. |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROPATHIC PAIN ; ADULT NEUROGENESIS ; BACK-PAIN ; BRAIN ; NEURONS ; STIMULATION ; TRANSITION ; PATHWAYS |
资助项目 | National Basic Research Program of the Ministry of Science and Technology of China[2014CB548200] ; National Basic Research Program of the Ministry of Science and Technology of China[2015CB554503] ; National Natural Science Foundation of China[91732107] ; National Natural Science Foundation of China[81571067] ; National Natural Science Foundation of China[81521063] ; National Natural Science Foundation of China[31872774] ; National Natural Science Foundation of China[81974166] ; Beijing Natural Science Foundation[5182013] ; Key Project of the Chinese Ministry of Education[109003] ; 111'' Project of the Ministry of Education of China[B07001] |
WOS研究方向 | Cell Biology |
语种 | 英语 |
出版者 | CELL PRESS |
WOS记录号 | WOS:000495045400016 |
资助机构 | National Basic Research Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Key Project of the Chinese Ministry of Education ; 111'' Project of the Ministry of Education of China |
源URL | [http://ir.psych.ac.cn/handle/311026/30789] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wan, You; Yi, Ming |
作者单位 | 1.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 4.Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing 100083, Peoples R China 5.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100083, Peoples R China 6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Longyu,Yue, Lupeng,Zhang, Yuqi,et al. Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation[J]. CELL REPORTS,2019,29(6):1579-+. |
APA | Ma, Longyu.,Yue, Lupeng.,Zhang, Yuqi.,Wang, Yue.,Han, Bingxuan.,...&Yi, Ming.(2019).Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation.CELL REPORTS,29(6),1579-+. |
MLA | Ma, Longyu,et al."Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation".CELL REPORTS 29.6(2019):1579-+. |
入库方式: OAI收割
来源:心理研究所
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