中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation

文献类型:期刊论文

作者Ma, Longyu1,5; Yue, Lupeng2,3; Zhang, Yuqi1,5; Wang, Yue1,5; Han, Bingxuan1,5; Cui, Shuang1,5; Liu, Feng-Yu1,5; Wan, You1,4,5,6; Yi, Ming1,4,5
刊名CELL REPORTS
出版日期2019-11-05
卷号29期号:6页码:1579-+
ISSN号2211-1247
DOI10.1016/j.celrep.2019.10.002
产权排序3
文献子类article
英文摘要

Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous brain activity and continuous neuroplastic changes of relevant circuits. Activity in the hippocampus-medial prefrontal cortex (mPFC) pathway has been suggested to correlate with spontaneous pain and pain chronicity, but causal evidence is lacking. Here we combine longitudinal in vivo electrophysiological recording with behavioral testing and show that persistent spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex (vCA1-IL) connectivity and hippocampal modulation of IL neuronal activity in rats with peripheral inflammation. Chemo- and optogenetic rescue of vCA1-IL dysfunction relieves spontaneous pain. Circuit-specific overexpression of brain-derived neurotrophic factor (BDNF) in vCA1-IL reverses electrophysiological changes, relieves spontaneous pain, and accelerates overall recovery from inflammatory pain. Our work identifies a neural pathway that specifically correlates with spontaneous pain and supports the significance of using a circuit dynamics-based strategy for more comprehensive understanding of circuitry mechanisms underlying chronic pain.

WOS关键词MEDIAL PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROPATHIC PAIN ; ADULT NEUROGENESIS ; BACK-PAIN ; BRAIN ; NEURONS ; STIMULATION ; TRANSITION ; PATHWAYS
资助项目National Basic Research Program of the Ministry of Science and Technology of China[2014CB548200] ; National Basic Research Program of the Ministry of Science and Technology of China[2015CB554503] ; National Natural Science Foundation of China[91732107] ; National Natural Science Foundation of China[81571067] ; National Natural Science Foundation of China[81521063] ; National Natural Science Foundation of China[31872774] ; National Natural Science Foundation of China[81974166] ; Beijing Natural Science Foundation[5182013] ; Key Project of the Chinese Ministry of Education[109003] ; 111'' Project of the Ministry of Education of China[B07001]
WOS研究方向Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:000495045400016
资助机构National Basic Research Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Key Project of the Chinese Ministry of Education ; 111'' Project of the Ministry of Education of China
源URL[http://ir.psych.ac.cn/handle/311026/30789]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wan, You; Yi, Ming
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
4.Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing 100083, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100083, Peoples R China
6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China
推荐引用方式
GB/T 7714
Ma, Longyu,Yue, Lupeng,Zhang, Yuqi,et al. Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation[J]. CELL REPORTS,2019,29(6):1579-+.
APA Ma, Longyu.,Yue, Lupeng.,Zhang, Yuqi.,Wang, Yue.,Han, Bingxuan.,...&Yi, Ming.(2019).Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation.CELL REPORTS,29(6),1579-+.
MLA Ma, Longyu,et al."Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation".CELL REPORTS 29.6(2019):1579-+.

入库方式: OAI收割

来源:心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。