Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampus
文献类型：期刊论文
| 作者 | Mahakizadeh, Simin2; Mokhtari, Tahmineh1,3; Navaee, Fatemeh4; Poorhassan, Mahnaz4; Tajik, Armin5; Hassanzadeh, Gholamreza6 |
| 刊名 | JOURNAL OF CHEMICAL NEUROANATOMY
 |
| 出版日期 | 2020-03-01 |
| 卷号 | 104页码:9 |
| 关键词 | Hypoxia Alzheimer's disease Dementia Inflammation seladin-1 Memory impairment |
| ISSN号 | 0891-0618 |
| DOI | 10.1016/j.jchemneu.2020.101744 |
| 通讯作者 | Hassanzadeh, Gholamreza(hassanzadeh@tums.ac.ir) |
| 英文摘要 | Background: There are evidences showing the relation between chronic hypoxia and Alzheimer's disease (AD) as a metabolic neurodegenerative disease. This study was designed to evaluate the effects of chronic hypoxia on factors which characterized in AD to introduce a new model of AD-dementia. Methods and materials: Twenty-four male rats were randomly divided in three groups: Control group (Co), Sham group (Sh), Hypoxia induction group (Hx, exposed to hypoxic chamber [oxygen 8% and nitrogen 92%] for 30 days, 4 h/day). Spatial learning and memory were analyzed using the Morris water maze task. At day 30 after hypoxia period, animals were sacrificed and serum was gathered for pro-inflammatory cytokines (interleukin-1 beta and tumor necrosis factor) measurements and brains were used for molecular and histopathological investigations. Results: According to behavioral studies, a significant impairment was seen in Hx group (P < 0.05). TNF-alpha and IL-1 beta showed a significant enhanced in Hx group comparing with Co group and Sh group (P < 0.05). As well, the gene expression of seladin-1, Tuj1 and the number of seladin-1 +, Tuj1 +neurons significantly decreased and also the mean number of dark neurons significantly increased in CA1 and CA3 regions of hippocampus. Conclusions: In this study, a new model of AD was developed which showed the underlying mechanisms of AD and its relations with chronic hypoxia. Hypoxia for 30 days decreased seladin-1, Tuj1 expression, increased the number of dark neurons, and also induced memory impairment. These results indicated that chronic hypoxia mediated the dementia underlying AD and AD-related pathogenesis in rat. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; ALZHEIMERS-DISEASE ; MECHANISMS ; MODEL ; RAT ; PATHOGENESIS ; CELLS |
| 资助项目 | Tehran University of Medical Sciences[94-02-30-28381] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000519655700015 |
| 出版者 | ELSEVIER |
| 资助机构 | Tehran University of Medical Sciences |
| 源URL | [http://ir.psych.ac.cn/handle/311026/31380]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Hassanzadeh, Gholamreza |
| 作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Alborz Univ Med Sci, Sch Med, Dept Anat, Karaj, Iran 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Shahidbeheshti Univ Med Sci, Sch Med, Dept Anat, Tehran, Iran 5.Alborz Univ Med Sci, Student Res Comm, Karaj, Iran 6.Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran |
| 推荐引用方式 GB/T 7714 | Mahakizadeh, Simin,Mokhtari, Tahmineh,Navaee, Fatemeh,et al. Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampus[J]. JOURNAL OF CHEMICAL NEUROANATOMY,2020,104:9. |
| APA | Mahakizadeh, Simin,Mokhtari, Tahmineh,Navaee, Fatemeh,Poorhassan, Mahnaz,Tajik, Armin,&Hassanzadeh, Gholamreza.(2020).Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampus.JOURNAL OF CHEMICAL NEUROANATOMY,104,9. |
| MLA | Mahakizadeh, Simin,et al."Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampus".JOURNAL OF CHEMICAL NEUROANATOMY 104(2020):9. |
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来源：心理研究所
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