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Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome

文献类型：期刊论文

作者Tian, Hong1; Yu, Yanbing1; Zhen, Xueke1; Zhang, Li1; Yuan, Yue1; Zhang, Bo4; Wang, Liang2,3
刊名STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
出版日期2019
卷号97期号:5-6页码:356-361
关键词Meige syndrome Deep brain stimulation Globus pallidus internus Clinical effects Long-term efficacy
ISSN号1011-6125
DOI10.1159/000504861
通讯作者Yu, Yanbing(yyb5185@126.com) ; Wang, Liang(lwang@psych.ac.cn)
英文摘要Objective: Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) is an alternative therapy in ameliorating the clinical symptoms of primary Meige syndrome. Nevertheless, proof of its efficacy and safety is insufficient due to several case reports and small-sample clinical studies. This study aims to investigate postoperative long-term efficacy in patients undergoing DBS of the GPi for primary Meige syndrome. Methods: We performed a retrospective study to assess the efficacy and safety of bilateral GPi stimulation in 40 patients with primary Meige syndrome who responded poorly to medical treatments or botulinum toxin injections. All participants were postoperatively followed up at the outpatient clinic, and their motor functions were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). The severity of patients' dystonia was evaluated before surgery and at follow-up neurostimu-lation. Results: The implanted stimulator was turned on 1 month after surgery. All 40 patients received monopolar stimulation using the following parameters: voltage 2.5-3.5 V (average: 2.6 +/- 0.8 V), frequency 60-160 Hz (average: 88.0 +/- 21.3 Hz), and pulse width 60-185 mu S (average: 90.0 +/- 21.1 mu S). In 28 of 40 patients, the symptoms had signifi-cantly improved within 1 week of stimulation. Most of the patients had been followed up for 6-24 months (average: 15.0 +/- 7.8 months). The clinical symptoms of all patients had significantly improved. At 6, 12, and 24 months after surgery, the BFMDRS subscores of eyes, mouth, speech, and swallowing were significantly lower, and subscores of mouth movement showed progressively decreased with prolonged stimulation time. The overall improvement rate was 83%. Five adverse events occurred in the 40 patients; all of these events resolved without permanent sequelae. Conclusions: Bilateral GPi-DBS demonstrated satisfactory long-term efficacy in the treatment of primary Meige syndrome and could serve as an effective and safe option.
WOS关键词DYSTONIA ; BLEPHAROSPASM
资助项目Strategic Priority Research Program of the Chinese Academy of Science[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Natural Science Foundation of China[31771255]
WOS研究方向Neurosciences & Neurology ; Surgery
语种英语
WOS记录号WOS:000516593300008
出版者KARGER
资助机构Strategic Priority Research Program of the Chinese Academy of Science ; Beijing Municipal Science and Technology Commission ; CAS Interdisciplinary Innovation Team ; Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/31404]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Yu, Yanbing; Wang, Liang
作者单位1.China Japan Friendship Hosp, Dept Neurosurg, Beijing 100029, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Zunyi Med Univ, Key Lab Brain Sci, Zunyi, Guizhou, Peoples R China
推荐引用方式
GB/T 7714		 Tian, Hong,Yu, Yanbing,Zhen, Xueke,et al. Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome[J]. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,2019,97(5-6):356-361.
APA Tian, Hong.,Yu, Yanbing.,Zhen, Xueke.,Zhang, Li.,Yuan, Yue.,...&Wang, Liang.(2019).Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome.STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,97(5-6),356-361.
MLA Tian, Hong,et al."Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome".STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 97.5-6(2019):356-361.

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来源：心理研究所

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