High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia
文献类型：期刊论文
| 作者 | Guan, Heng Yong7; Zhao, Jian Min7; Wang, Ke Qiang7; Su, Xiu Ru7; Pan, Yan Fen7; Guo, Jin Ming7; Jiang, Long7; Wang, Yu Hong7; Liu, Hong Yu7; Sun, Shi Guang7 |
| 刊名 | TRANSLATIONAL PSYCHIATRY
 |
| 出版日期 | 2020-02-25 |
| 卷号 | 10期号:1页码:9 |
| ISSN号 | 2158-3188 |
| DOI | 10.1038/s41398-020-0745-6 |
| 通讯作者 | Xiu, Mei Hong(xiumeihong@163.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Cognitive impairment is a central aspect of schizophrenia (SCZ) that occurs at the onset of the disease and is related to poor social function and outcome in patients with SCZ. Recent literatures have revealed repetitive transcranial magnetic stimulation (rTMS) to be one of the efficient medical interventions for cognitive impairments. However, no study has been conducted to investigate the treatment effectiveness of 20 Hz rTMS with neuronavigation system administered to the left dorsolateral prefrontal cortex (DLPFC) in patients with schizophrenia. In this randomized, double-blind and sham-controlled study, 56 patients were enrolled in 20 Hz rTMS (n = 28) or sham stimulation (n = 28) over left DLPFC for 8 weeks. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to measure the cognitive function at baseline and after 8 weeks of rTMS treatment. The positive and negative syndrome scales (PANSS) was performed to assess the clinical symptoms at baseline, after 2-week treatment, 4-week treatment, 6-week treatment, and 8-week treatment. Totally, 15 subjects (seven in active group and eight in sham group) dropped out during the trial and the main findings were from completed 41 patients. At 2 weeks, 4 weeks, and 6 weeks, there were no significant differences in PANSS total score and subscores between the sham and treatment groups. At 8 weeks, the 20 Hz rTMS significantly increased the immediate memory score compared with the sham. Furthermore, the improvement in the immediate memory score was correlated with the decrease in the excitement factor score of the patients with SCZ. Our results suggest that 20 Hz rTMS appears to be an effective treatment for improving the cognitive performance and reducing the clinical symptoms of patients with SCZ. |
| WOS关键词 | TRANSCRANIAL MAGNETIC STIMULATION ; AUDITORY VERBAL HALLUCINATIONS ; PREDOMINANT NEGATIVE SYMPTOMS ; MAJOR DEPRESSION ; PREFRONTAL CORTEX ; EFFICACY ; METAANALYSIS ; MULTISITE ; DOPAMINE ; SAFETY |
| 资助项目 | Scientific and Technological Program of Hebei[20150593] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000519575200002 |
| 资助机构 | Scientific and Technological Program of Hebei |
| 源URL | [http://ir.psych.ac.cn/handle/311026/31410]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Xiu, Mei Hong; Zhang, Xiang Yang |
| 作者单位 | 1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Beijing, Peoples R China 5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 7.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Heng Yong,Zhao, Jian Min,Wang, Ke Qiang,et al. High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):9. |
| APA | Guan, Heng Yong.,Zhao, Jian Min.,Wang, Ke Qiang.,Su, Xiu Ru.,Pan, Yan Fen.,...&Zhang, Xiang Yang.(2020).High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),9. |
| MLA | Guan, Heng Yong,et al."High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):9. |
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来源：心理研究所
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