中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout

文献类型：期刊论文

作者He, Shu-Chang2,4; Wu, Shuang2,4; Wang, Chao2,4; Wang, Dong-Mei1,3; Wang, Jiesi1,3; Xu, Hang1,3; Wang, Li1,3; Zhang, Xiang Yang1,3
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2020-04-01
卷号266页码:671-677
ISSN号0165-0327
关键词Job stress Burnout Gene polymorphism sBDNF
DOI10.1016/j.jad.2020.01.181
通讯作者He, Shu-Chang(shuchangh@pku.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Background: Some studies have shown that long-term exposure to job stress could result in burnout, and BDNF polymorphism may play an important role in its psychopathological mechanism. However, the inter-relationships between the job-related stress, serum BDNF level, BDNF genotype and job burnout have not been examined. This study was to explore the job stress x BDNF rs2049046 interaction and the role of serum BDNF level in job burnout in a Chinese Han population. Methods: Using a cross-sectional design, 205 healthy subjects were recruited from a public institution in Beijing and assessed for job stress using the House and Rizzo's Work Stress Scale, and job burnout using the Maslach Burnout Inventory (MBI). The BDNF rs2049046 polymorphism was genotyped and serum BDNF (sBDNF) levels were assayed in all of subjects. Results: The correlations between the job stress score and two burnout subscale scores (emotional exhaustion and cynicism) were significant (both p < 0.001), but not with professional efficacy. There were no significant main effects of the BDNF rs2049046 genotype on burnout, and no significant correlation was observed between sBDNF levels and job burnout. However, the interaction between the job stress and the BDNF rs2049046 genotype (F = 2.709, df = 2, 183, p = 0.032) or between the job stress and sBDNF levels on burnout was significant (t = - 2.132, p = 0.035). To be specific, the individuals with the BDNF rs2049046 AT genotype showed a greater susceptibility to the burnout cynicism compared to AA homozygote only in medium-stress group (F = 4.327, df = 1,117, p = 0.015). The individuals who had lower sBDNF showed higher burnout level than those who had higher sBDNF in low-stress group. Conclusions: Our findings suggest that the BDNF system may interact with job stress to affect burnout, showing that interaction between BDNF rs2049046 and job stress or the interaction between BDNF levels with work stress on certain burnout dimensions.
WOS关键词NEUROTROPHIC FACTOR ; COGNITIVE IMPAIRMENT ; METHYLATION ; DEPRESSION ; DISORDER ; VAL66MET ; BIPOLAR ; PATHWAY ; AXIS
资助项目National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81871060]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000520892700087
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/31525]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者He, Shu-Chang; Zhang, Xiang Yang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714		 He, Shu-Chang,Wu, Shuang,Wang, Chao,et al. Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,266:671-677.
APA He, Shu-Chang.,Wu, Shuang.,Wang, Chao.,Wang, Dong-Mei.,Wang, Jiesi.,...&Zhang, Xiang Yang.(2020).Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout.JOURNAL OF AFFECTIVE DISORDERS,266,671-677.
MLA He, Shu-Chang,et al."Interaction between job stress, serum BDNF level and the BDNF rs2049046 polymorphism in job burnout".JOURNAL OF AFFECTIVE DISORDERS 266(2020):671-677.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。