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Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder

文献类型：期刊论文

作者Wang, Kui2,3; Zhao, Yan-li1; Tan, Shu-ping1; Zhang, Jin-guo1; Li, Dong1; Chen, Jing-xu1; Zhang, Li-gang1; Yu, Xin-yang2,3; Zhao, Dan6; Cheung, Eric F. C.5
刊名PSYCH JOURNAL
出版日期2020-04-01
卷号9期号:2页码:247-257
ISSN号2046-0252
关键词bipolar disorder discriminant analysis event-related potentials (ERPs) N400 schizophrenia semantic priming
DOI10.1002/pchj.321
通讯作者Wang, Kui(wangk@psych.ac.cn) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Impairment in semantic association has been reported in bipolar disorder (BD) and schizophrenia (SZ) patients and could underlie abnormal speech patterns in both disorders. In this study, we compared the electrophysiological semantic processing features in patients with these two disorders. Participants (n = 61; BD = 19; SZ = 19; healthy controls [HCs] = 23) were administered a semantic judgment task and event-related potentials (ERPs) were recorded. Responses of the two patient groups were significantly slower than HCs, but comparable behavioral semantic priming effects were observed in both patient groups. The N400 priming effect was observed in all groups, with a delayed peak in the two patient groups. The N400 effect was enhanced for both BD and SZ patients over the left frontal and frontal pole region, but SZ patients showed additional reduction of N400 over the right posterior and occipital regions. The N400 mean amplitudes for related targets correlated with less severe negative symptoms in patients with SZ. Discriminant functional analysis using reaction time and N400 measures successfully classified 82% of the participants into their respective clinical groups. These results suggest that patients with BD and SZ have both overlapping and distinctive semantic processing dysfunction. These findings are consistent with the continuum conceptualization of these disorders, but also offer some support for the traditional Kraepelinian dichotomy.
WOS关键词ELECTROPHYSIOLOGICAL INSIGHTS ; N400 ABNORMALITIES ; ACTIVATION ; IMPAIRMENT ; ATTENTION ; LANGUAGE ; MANIA ; SCALE
WOS研究方向Psychology
语种英语
出版者WILEY
WOS记录号WOS:000526789700010
源URL[http://ir.psych.ac.cn/handle/311026/31547]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Kui; Chan, Raymond C. K.
作者单位1.Beijing Huilongguan Hosp, Beijing, Peoples R China
2.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
5.Castle Peak Hosp, Hong Kong, Peoples R China
6.Changchun Normal Univ, Sch Educ, Changchun, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Kui,Zhao, Yan-li,Tan, Shu-ping,et al. Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder[J]. PSYCH JOURNAL,2020,9(2):247-257.
APA Wang, Kui.,Zhao, Yan-li.,Tan, Shu-ping.,Zhang, Jin-guo.,Li, Dong.,...&Chan, Raymond C. K..(2020).Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder.PSYCH JOURNAL,9(2),247-257.
MLA Wang, Kui,et al."Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder".PSYCH JOURNAL 9.2(2020):247-257.

入库方式： OAI收割

来源：心理研究所

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