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Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

文献类型：期刊论文

作者Wang, Yong-ming9,10,11,12; Yang, Zhuo-ya9,12; Cai, Xin-lu9,10,11,12; Zhou, Han-yu9,12; Zhang, Rui-ting9,12; Yang, Han-xue9,12; Liang, Yun-si9,10,11,12; Zhu, Xiong-zhao1,13; Madsen, Kristoffer Hougaard2,8,11; Sorensen, Thomas Alrik7,11
刊名SCHIZOPHRENIA BULLETIN
出版日期2020-03-01
卷号46期号:2页码:442-453
关键词diffusion tensor imaging schizo-obsessive comorbidity schizophrenia obsessive-compulsive disorder support vector classification
ISSN号0586-7614
DOI10.1093/schbul/sbz073
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.
WOS关键词COMPULSIVE DISORDER OCD ; NEUROLOGICAL SOFT SIGNS ; WHITE-MATTER INTEGRITY ; FREE-WATER ELIMINATION ; SCHIZOPHRENIA PREVALENCE ; COGNITIVE DEFICITS ; BED NUCLEUS ; BDNF GENE ; HIGH-RISK ; CONNECTIVITY
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Strategic Priority Research Programme (B) of the Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000525861400027
出版者OXFORD UNIV PRESS
资助机构National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; Strategic Priority Research Programme (B) of the Chinese Academy of Science ; CAS Key Laboratory of Mental Health, Institute of Psychology
源URL[http://ir.psych.ac.cn/handle/311026/31562]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Cent South Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
2.Copenhagen Univ Hosp Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Copenhagen, Denmark
3.Castle Peak Hosp, Hong Kong, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
5.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
6.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
7.Aalborg Univ, Ctr Cognit Neurosci, Dept Commun & Psychol, Aalborg, Denmark
8.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
9.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
10.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yong-ming,Yang, Zhuo-ya,Cai, Xin-lu,et al. Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography[J]. SCHIZOPHRENIA BULLETIN,2020,46(2):442-453.
APA Wang, Yong-ming.,Yang, Zhuo-ya.,Cai, Xin-lu.,Zhou, Han-yu.,Zhang, Rui-ting.,...&Chan, Raymond C. K..(2020).Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography.SCHIZOPHRENIA BULLETIN,46(2),442-453.
MLA Wang, Yong-ming,et al."Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography".SCHIZOPHRENIA BULLETIN 46.2(2020):442-453.

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来源：心理研究所

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