Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia
文献类型:期刊论文
作者 | Kong, Li1,2; Herold, Christina J.3; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5; Schroeder, Johannes3 |
刊名 | SCHIZOPHRENIA BULLETIN |
出版日期 | 2020-05-01 |
卷号 | 46期号:3页码:562-571 |
ISSN号 | 0586-7614 |
关键词 | neurological soft signs gray matter structural brain network schizophrenia graph theoretical approach network characteristics |
DOI | 10.1093/schbul/sbz118 |
产权排序 | 2 |
文献子类 | article |
英文摘要 | Neurological soft signs (NSS) are often found in patients with schizophrenia. A wealth of neuroimaging studies have reported that NSS are related to disturbed cortical-subcortical-cerebellar circuitry in schizophrenia. However, the association between NSS and brain network abnormalities in patients with schizophrenia remains unclear. In this study, the graph theoretical approach was used to analyze brain network characteristics based on structural magnetic resonance imaging (MRI) data. NSS were assessed using the Heidelberg scale. We found that there was no significant difference in global network properties between individuals with high and low levels of NSS. Regional network analysis showed that NSS were associated with betweenness centrality involving the inferior orbital frontal cortex, the middle temporal cortex, the hippocampus, the supramarginal cortex, the amygdala, and the cerebellum. Global network analysis also demonstrated that NSS were associated with the distribution of network hubs involving the superior medial frontal cortex, the superior and middle temporal cortices, the postcentral cortex, the amygdala, and the cerebellum. Our findings suggest that NSS are associated with alterations in topological attributes of brain networks corresponding to the cortical-subcortical-cerebellum circuit in patients with schizophrenia, which may provide a new perspective for elucidating the neural basis of NSS in schizophrenia. |
WOS关键词 | GRAPH-THEORETICAL ANALYSIS ; SMALL-WORLD ; SENSORIMOTOR CORTEX ; CORTICAL THICKNESS ; ORGANIZATION ; DYSFUNCTION ; MORPHOLOGY ; PSYCHOSIS ; CONNECTIVITY ; GYRIFICATION |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China[81601170] |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | OXFORD UNIV PRESS |
WOS记录号 | WOS:000525862800014 |
资助机构 | National Key Research and Development Programme ; Beijing Training Project for the Leading Talents in Science and Technology ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China |
源URL | [http://ir.psych.ac.cn/handle/311026/31568] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Shanghai Normal Univ, Coll Educ, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Heidelberg Univ, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, Germany 4.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,et al. Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(3):562-571. |
APA | Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,Chan, Raymond C. K.,&Schroeder, Johannes.(2020).Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia.SCHIZOPHRENIA BULLETIN,46(3),562-571. |
MLA | Kong, Li,et al."Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia".SCHIZOPHRENIA BULLETIN 46.3(2020):562-571. |
入库方式: OAI收割
来源:心理研究所
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