Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies
文献类型：期刊论文
| 作者 | Zhang, Chun-Jing3; Guo, Jian-You2 ; Cheng, Hao5; Lin, Li1; Liu, Ying3; Shi, Yan3; Xu, Jing3; Yu, Hai-Tao4
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| 刊名 | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
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| 出版日期 | 2020 |
| 卷号 | 22期号:4页码:325-333 |
| 关键词 | Pleurotus eryngii polysaccharides Alzheimer's disease beta-amyloid PC12 cells neuroprotection medicinal mushrooms |
| ISSN号 | 1521-9437 |
| DOI | 10.1615/IntJMedMushrooms.2020033990 |
| 通讯作者 | Yu, Hai-Tao(yht422@126.com) |
| 英文摘要 | Pleurotus eryngii (PE) contains polysaccharides and vitamins, and has been reported to have antidepression properties. P. eryngii polysaccharides (PEP) are one of the main components. Modulation of beta-amyloid-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease (AD). The present study aimed to evaluate the protective effect of PEP on beta-amyloid-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells and aging rats. After 28 weeks' treatment, exposure of PC12 cells to P. eryngii polysaccharides significantly elevated cell viability, decreased the levels of intracellular calcium, and attenuated the beta-amyloid-mediated cell apoptosis. In aging rats, P. eryngii polysaccharides could decrease the production of APP in the brain by an action that is associated with a lowering of the iNOS, and COX-2 level. Our findings indicated that P. eryngii polysaccharides had potential neuroprotective actions against beta-amyloid-induced neurotoxicity, which might be through modulating calcium channels, or downstream molecules involved in inflammation. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; CYCLOOXYGENASE-2 ; APOPTOSIS ; PRECURSOR ; EXTRACT ; PROTEIN |
| 资助项目 | Postdoctoral Researcher of Heilongjiang Postdoctoral Management Office[LBH-Q16225] ; Qiqihar Medical University[QY2016LX-01] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000536225900002 |
| 出版者 | BEGELL HOUSE INC |
| 资助机构 | Postdoctoral Researcher of Heilongjiang Postdoctoral Management Office ; Qiqihar Medical University |
| 源URL | [http://ir.psych.ac.cn/handle/311026/31976]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Yu, Hai-Tao |
| 作者单位 | 1.Qiqihar Med Univ, Dept Clin Biochem, Qiqihar 161006, Heilongjiang, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 3.Qiqihar Med Univ, Dept Biochem, Qiqihar 161006, Heilongjiang, Peoples R China 4.Qiqihar Med Univ, Dept Biol Genet, Qiqihar 161006, Heilongjiang, Peoples R China 5.Qiqihar Med Univ, Affiliated Hosp 3, Qiqihar 161006, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chun-Jing,Guo, Jian-You,Cheng, Hao,et al. Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2020,22(4):325-333. |
| APA | Zhang, Chun-Jing.,Guo, Jian-You.,Cheng, Hao.,Lin, Li.,Liu, Ying.,...&Yu, Hai-Tao.(2020).Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,22(4),325-333. |
| MLA | Zhang, Chun-Jing,et al."Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 22.4(2020):325-333. |
入库方式： OAI收割
来源：心理研究所
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