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Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia

文献类型：期刊论文

作者Gao, Jie2; Xiu, Mei Hong3; Liu, Dian Ying4; Wei, Chang Wei5; Zhang, Xiangyang1
刊名AGING-US
出版日期2020-06-15
卷号12期号:11页码:10290-10299
关键词schizophrenia symptoms cognition MTHFR polymorphism
ISSN号1945-4589
DOI10.18632/aging.103248
通讯作者Wei, Chang Wei(changwei.wei@ccmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要The etiology of schizophrenia is still unknown, and the MTHFR gene has been shown to be associated with SCZ. Previous studies have shown that patients with schizophrenia exhibit sex differences in symptoms and cognitive function. However, no study has been conducted to investigate the sex difference in the association between C677T polymorphism and symptoms and cognitive impairment in Chinese patients with schizophrenia. The C677T polymorphism was genotyped in 957 patients with schizophrenia and 576 controls. Patients were also rated on the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The results showed that there were significant differences in MTHFR C677T genotype and allele distributions between male patients and male controls (both p<0.05), while there was no significant difference between female patients and female controls (both p>0.05). Further analysis showed that there were significant sex differences in the association between C677T genotype and negative symptoms, immediate memory or attention index score in schizophrenia (p<0.05). This study suggests that the complex interactive effect between MTHFR C677T polymorphism and sex plays an important role in some clinical characteristics of patients with schizophrenia.
WOS关键词GENDER-DIFFERENCES ; BIPOLAR DISORDER ; EXECUTIVE FUNCTION ; GENE POLYMORPHISM ; NEGATIVE SYMPTOMS ; DNA METHYLATION ; HOMOCYSTEINE ; ASSOCIATION ; FOLATE ; BRAIN
资助项目National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Beijing Natural Science Foundation[7194270] ; Beijing Hospitals Authority Youth Programme[QML20190307]
WOS研究方向Cell Biology ; Geriatrics & Gerontology
语种英语
WOS记录号WOS:000540580800022
出版者IMPACT JOURNALS LLC
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Hospitals Authority Youth Programme
源URL[http://ir.psych.ac.cn/handle/311026/32076]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wei, Chang Wei; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Capital Med Univ, Beijing Chao Yang Hosp, Dept Cardiac Surg, Beijing, Peoples R China
3.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
4.Third Peoples Hosp Ganzhou, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China
5.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,et al. Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia[J]. AGING-US,2020,12(11):10290-10299.
APA Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,Wei, Chang Wei,&Zhang, Xiangyang.(2020).Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia.AGING-US,12(11),10290-10299.
MLA Gao, Jie,et al."Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia".AGING-US 12.11(2020):10290-10299.

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来源：心理研究所

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