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Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality

文献类型：期刊论文

作者Li, Yuling2,4; Cao, Zeyuan1,2,4; Wu, Shuang2,4; Wang, Chao2,4; He, Shuchang2,4; Dong, Yan3; Zhang, Xiangyang5
刊名JOURNAL OF SLEEP RESEARCH
出版日期2020-07-07
页码10
ISSN号0962-1105
关键词CLOCKgene daytime dysfunction job stress rs11932595 single-nucleotide polymorphism (SNP) sleep duration
DOI10.1111/jsr.13133
通讯作者He, Shuchang(shuchangh@pku.edu.cn) ; Dong, Yan(dong8958@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Job stress and the Circadian Locomotor Output Cycles Kaput (CLOCK) gene could affect circadian rhythm and sleep quality. The main aim of our present study was to investigate the association of job stress,CLOCKgene polymorphism and their interaction with sleep quality in a non-clinical Chinese Han population, which has not been reported to date. Using a cross-sectional design, 450 subjects were recruited in Beijing. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and job stress was measured with the Work Stress Scale.CLOCKgene rs11932595 polymorphism was genotyped in 297 blood samples. Correlation analysis showed a close but different association of high job stress with the PSQI and its components. Analysis of variance showed significant main effects of theCLOCKgene rs11932595 polymorphism. G-allele carriers had a higher score in the PSQI, sleep duration, sleep latency and sleep disturbances. Further interaction analyses showed an ordinal interaction on sleep duration, and a disordinal interaction on daytime dysfunction. Specifically, G-allele carriers had poorer sleep duration than AA homozygotes when in high job stress, while the two subgroups displayed similar sleep duration when in low job stress, conforming to the diathesis-stress model. In comparison to G-allele carriers, AA homozygotes experienced less daytime dysfunction when in low job stress whereas more daytime dysfunction when in high job stress, fitting with the differential susceptibility model. As genetic links have been revealed, our investigation might be conducive for elucidating aetiological factors for sleep quality and targets for implementing interventions to attain good sleep quality.
WOS关键词ENVIRONMENTAL-INFLUENCES ; 3111T/C POLYMORPHISM ; CLOCK GENES ; LIFE EVENTS ; STRESS ; WORK ; DISTURBANCES ; DEPRESSION ; PREFERENCE ; SAMPLE
资助项目National Natural Science Foundation of China[81871060] ; National Natural Science Foundation of China[81571322]
WOS研究方向Neurosciences & Neurology
语种英语
出版者WILEY
WOS记录号WOS:000545732100001
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/32190]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者He, Shuchang; Dong, Yan; Zhang, Xiangyang
作者单位1.Boston Univ, Bioinformat Program, Boston, MA 02215 USA
2.Peking Univ, Sch Psychol & Cognit Sci, Beijing, Peoples R China
3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Healthy, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yuling,Cao, Zeyuan,Wu, Shuang,et al. Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality[J]. JOURNAL OF SLEEP RESEARCH,2020:10.
APA Li, Yuling.,Cao, Zeyuan.,Wu, Shuang.,Wang, Chao.,He, Shuchang.,...&Zhang, Xiangyang.(2020).Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality.JOURNAL OF SLEEP RESEARCH,10.
MLA Li, Yuling,et al."Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality".JOURNAL OF SLEEP RESEARCH (2020):10.

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来源：心理研究所

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