CACNB2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania
文献类型:期刊论文
作者 | Chen, Jianshan9; Tan, Jiuwei9; Greenshaw, Andrew J.8; Sawalha, Jeff8; Liu, Yang8; Zhang, Xiaofei9; Zou, Wenjin9; Cheng, Xiaofang9; Deng, Wenhao9; Zhang, Yizhi7,9 |
刊名 | JOURNAL OF AFFECTIVE DISORDERS |
出版日期 | 2020-05-01 |
卷号 | 268页码:82-87 |
ISSN号 | 0165-0327 |
关键词 | Bipolar disorder First episode CACNB2 rs11013860 Prefrontal cortex Imaging |
DOI | 10.1016/j.jad.2020.02.007 |
文献子类 | article |
英文摘要 | Background: The beta 2 subunit of the voltage-gated c-type calcium channel gene(CACNB2) rs11013860 polymorphism is a putative genetic susceptibility marker for bipolar disorder (BD). However, the neural effects of CACNB2 rs11013860 in BD are largely unknown. Methods: Forty-six bipolar patients with first-episode mania and eighty-three healthy controls (HC) were genotyped for CACNB2 rs11013860 and were scanned with a 3.0 Tesla structural magnetic resonance imaging system to measure cortical thickness of prefrontal cortex (PFC) components (superior frontal cortex, orbito-frontal cortex, middle and inferior frontal gyri). Results: Cortical thickness was thinner in patients on all PFC measurements compared to HC (p < 0.050). Moreover, we found a significant interaction between CACNB2 genotype and diagnosis for the right superior frontal cortical thickness (F = 8.190, p = 0.040). Bonferroni corrected post-hoc tests revealed that, in CACNB2 A-allele carriers, patients displayed thinner superior frontal thickness compared to HC < 0.001). In patients, CACNB2 A-allele carriers also exhibited reduced superior frontal thickness compared to CACNB2 CC-allele carriers (p = 0.016). Limitations: Lithium treatment may influence our results, and the sample size in our study is relatively small. Conclusions: Our results suggest that the CACNB2 rs11013860 might impact PFC thickness in patients with first-episode mania. These findings provide evidence to support CACNB2 rs11013860 involvement in the emotion-processing neural circuitry abnormality in the early stage of BD, which will ultimately contribute to revealing the link between the variation in calcium channel genes and the neuropathological mechanism of BD. |
WOS关键词 | GENOME-WIDE ASSOCIATION ; HUMAN CEREBRAL-CORTEX ; MEMORY PERFORMANCE ; HIPPOCAMPAL VOLUME ; CALCIUM-CHANNEL ; BETA-SUBUNITS ; WHITE-MATTER ; DISORDER ; CACNA1C ; ABNORMALITIES |
资助项目 | National Key R&D Program of China[2016YFC1306804] ; National Natural Science Foundation of China[81771466] ; Natural Science Foundation of Guangdong Province, China[2018A030313283] ; Guangzhou Municipal Key Discipline in Medicine ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory[201805010009] ; Key Laboratory for Innovation Platform Plan, Science, and Technology Program of Guangzhou, China ; Science and Technology Planning Project of Guangdong Province of China[2017ZC0419] ; Key Laboratory for Innovation platform Plan, Science and Technology Program of Guangzhou, China ; NARSAD Young Investigator Grants of The Brain & Behavior Research Foundation ; Alberta Synergies in Alzheimer's and Related Disorders (SynAD) program |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000520891900010 |
资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Guangzhou Municipal Key Discipline in Medicine ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory ; Key Laboratory for Innovation Platform Plan, Science, and Technology Program of Guangzhou, China ; Science and Technology Planning Project of Guangdong Province of China ; Key Laboratory for Innovation platform Plan, Science and Technology Program of Guangzhou, China ; NARSAD Young Investigator Grants of The Brain & Behavior Research Foundation ; Alberta Synergies in Alzheimer's and Related Disorders (SynAD) program |
源URL | [http://ir.psych.ac.cn/handle/311026/31467] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Cao, Bo; Cao, Liping |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Nanning Fifth Peoples Hosp, Nanning, Guangxi Zhuang, Peoples R China 3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China 5.Univ Alberta, Dept Comp Sci, Edmonton, AB, Canada 6.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 7.Gen Hosp Southern Theater Command, Guangzhou, Guangdong, Peoples R China 8.Univ Alberta, Dept Psychiat, Edmonton, AB, Canada 9.Guangzhou Med Univ, Guangzhou HuiAi Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Jianshan,Tan, Jiuwei,Greenshaw, Andrew J.,et al. CACNB2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,268:82-87. |
APA | Chen, Jianshan.,Tan, Jiuwei.,Greenshaw, Andrew J..,Sawalha, Jeff.,Liu, Yang.,...&Cao, Liping.(2020).CACNB2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania.JOURNAL OF AFFECTIVE DISORDERS,268,82-87. |
MLA | Chen, Jianshan,et al."CACNB2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania".JOURNAL OF AFFECTIVE DISORDERS 268(2020):82-87. |
入库方式: OAI收割
来源:心理研究所
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