One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia
文献类型:期刊论文
作者 | Xia, Luyao1,2; Liu, Lei5; Hong, Xiaohong5; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Tian, Yang1,2; Dai, Qilong1,2 |
刊名 | NEUROPSYCHOPHARMACOLOGY |
出版日期 | 2020-04-29 |
页码 | 7 |
ISSN号 | 0893-133X |
DOI | 10.1038/s41386-020-0685-0 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | The core features of schizophrenia (SCZ) include cognitive deficits and impaired sensory gating represented by P50 inhibition deficits, which appear to be related to the alpha 7 nicotinic acetylcholine receptor (nAChR). An agonist of nAChR receptor may improve these defects. This study aimed to investigate how administering multiple doses of tropisetron, a partial agonist of nAChR, for 1 day would affect cognitive deficits and P50 inhibition deficits in SCZ patients. We randomized 40 SCZ non-smokers into a double-blind clinical trial with four groups: placebo, 5 mg/d, 10 mg/d, and 20 mg/d of oral tropisetron. Their P50 ratios were all more than 0.5 and they took risperidone at 3-6 mg/day for at least a month before participating in the experiment. We measured the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and P50 inhibition before and one day after treatment. After one day of treatment, the total RBANS scores of the 20 mg and 5 mg tropisetron groups, and the immediate memory of the 10 mg group were significantly higher than placebo group. The P50 ratio was smaller in the 5 mg and 10 mg groups than in the placebo group (both p < 0.05) after treatment. Furthermore, the improvement in RBANS total score was correlated with increased S1 latency (p < 0.05), and the increase in immediate memory score was correlated with decreased S2 amplitude. One day of treatment with tropisetron improved both cognitive and P50 inhibition deficits, suggesting that longer term treatment with alpha 7 nAChR agonists for these deficits in SCZ may be promising. |
WOS关键词 | NICOTINIC ACETYLCHOLINE-RECEPTOR ; NEUROPSYCHOLOGICAL STATUS ; REPEATABLE BATTERY ; SMOKING INITIATION ; CIGARETTE-SMOKING ; AGONIST ; RISPERIDONE ; TARGET ; METAANALYSIS ; ASSOCIATION |
资助项目 | National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000530248000002 |
资助机构 | National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program |
源URL | [http://ir.psych.ac.cn/handle/311026/31727] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Zhang, Xiang Yang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Shantou Univ, Mental Hlth Ctr, Shantou, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Luyao,Liu, Lei,Hong, Xiaohong,et al. One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2020:7. |
APA | Xia, Luyao.,Liu, Lei.,Hong, Xiaohong.,Wang, Dongmei.,Wei, Gaoxia.,...&Zhang, Xiang Yang.(2020).One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia.NEUROPSYCHOPHARMACOLOGY,7. |
MLA | Xia, Luyao,et al."One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia".NEUROPSYCHOPHARMACOLOGY (2020):7. |
入库方式: OAI收割
来源:心理研究所
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