Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study
文献类型:期刊论文
作者 | Wang, Yun1,2,3; Yan, Kai-Juan1,2,3; Fan, Chen-Xiao7; Luo, Xiao-Nian1,2,3; Zhou, Yuan1,2,3,4,5,6 |
刊名 | BMC NEUROSCIENCE |
出版日期 | 2019-12-30 |
卷号 | 20期号:1页码:10 |
ISSN号 | 1471-2202 |
关键词 | Resting-state functional connectivity Amphetamine-type stimulants abuse Nucleus accumbens Orbitofrontal cortex Inferior frontal gyrus |
DOI | 10.1186/s12868-019-0548-y |
产权排序 | 5 |
文献子类 | article |
英文摘要 | Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) during resting state. NAc contains different subdivisions and they may play different roles in addiction. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the NAc subdivisions in amphetamine-type stimulant abusers (ATSAs). Methods The present study recruited 17 male ATSAs and 22 healthy male controls. All the subjects underwent resting-state functional magnetic resonance imaging (fMRI) with their eyes closed. The NAc was divided into core-like and shell-like subdivisions. We used seed-based resting-state functional connectivity (RSFC) analyses to identify differences in brain functional architecture between ATSAs and healthy controls (HCs). Results ATSAs had lower positive RSFCs with all of the NAc subdivisions over the left orbital part of superior frontal gyrus and higher positive RSFCs with the NAc subdivisions over the left opercular part of inferior frontal gyrus than HCs, which indicates common abnormalities across the NAc subdivisions in ATSAs. In addition, the RSFCs between the NAc subdivisions and the left orbital part of superior frontal gyrus were negatively correlated with the addiction severity in ATSAs. Conclusion These results provide evidence that there are common RSFC patterns of the NAc subdivisions in ATSAs. The abnormality indicated by disrupted functional connectivity between the NAc subdivisions and prefrontal cortex suggests abnormal interaction between the rewarding process and cognitive control in ATSAs. Our results shed insight on the neurobiological mechanisms of ATSA and suggest potential novel therapeutic targets for treatment and intervention of ATSAs. |
WOS关键词 | RESPONSE-INHIBITION ; COGNITIVE CONTROL ; FRONTOSTRIATAL CIRCUITS ; CINGULATE CORTEX ; DRUG-ADDICTION ; BRAIN ; REWARD ; NEUROBIOLOGY ; ASSOCIATION ; INFORMATION |
资助项目 | National Key Technology R&D Program in the 12th Five-Year Plan of China[2012BAI01B07] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | BMC |
WOS记录号 | WOS:000511996200001 |
资助机构 | National Key Technology R&D Program in the 12th Five-Year Plan of China |
源URL | [http://ir.psych.ac.cn/handle/311026/30874] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Zhou, Yuan |
作者单位 | 1.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China 2.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 3.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 7.Second Hosp Jinhua City, Jinhua, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yun,Yan, Kai-Juan,Fan, Chen-Xiao,et al. Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study[J]. BMC NEUROSCIENCE,2019,20(1):10. |
APA | Wang, Yun,Yan, Kai-Juan,Fan, Chen-Xiao,Luo, Xiao-Nian,&Zhou, Yuan.(2019).Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study.BMC NEUROSCIENCE,20(1),10. |
MLA | Wang, Yun,et al."Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study".BMC NEUROSCIENCE 20.1(2019):10. |
入库方式: OAI收割
来源:心理研究所
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