中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院行为科学重点实验室
Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study

文献类型：期刊论文

作者Du, Yi6; Zhao, Jingjie6; Wang, Yongzhi6; Han, Yu5; Deng, Ligang4; Jia, Hongxiao3; Zhou, Yuan2,7; Su, Joyce1; Li, Li6
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
出版日期2020-02-18
卷号2020页码:9
ISSN号1741-427X
DOI10.1155/2020/7504917
通讯作者Li, Li(lili@ccmu.edu.cn)
英文摘要Major depressive disorder (MDD), especially combined with anxiety, has a high incidence and low detection rate in China. Literature has shown that patients under major depression with anxiety (MDA) are more likely to nominate a somatic, rather than psychological, symptom as their presenting complaint. In the theory of Traditional Chinese Medicine (TCM), clinical symptoms of MDD patients are mainly categorized into two different syndrome patterns: Deficiency and Excess. We intend to use resting-state functional magnetic resonance imaging (rs-fMRI) to investigate their brain functional differences and hopefully to find their brain function mechanism. For our research, 42 drug-naive MDA patients were divided into two groups (21 for Deficiency and 21 for Excess), with an additional 19 unaffected participants in the normal control (NC) group. We took Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), and brain fMRI scan for each group and analyzed the data. We first used Degree Centrality (DC) to map the functional differences in brain regions, utilized these regions as seed points, and used a seed-based functional connectivity (FC) analysis to identify the specific functional connection between groups. The Deficiency group was found to have higher HAMD scores, HAMA scores, and HAMD somatic factor than the Excess group. In the DC analysis, significant decreases were found in the right precuneus of both the Deficiency and Excess groups compared to the NC group. In the FC analysis, the right precuneus showed significant decreased network connectivity with the bilateral cuneus, as well as the right lingual gyrus in the Deficiency group when compared to the NC group and the Excess group. Through our research, it was found that precuneus dysfunction may have a relationship with MDA and Deficiency patients have more severe physical and emotional symptoms, and we realized that a larger sample size and multiple brain mode observations were needed in further research.
WOS关键词DEFAULT MODE NETWORK ; MEDICATION-NAIVE ; REGIONAL HOMOGENEITY ; PREFRONTAL CORTEX ; PRECUNEUS ; CONNECTIVITY ; 1ST-EPISODE ; DISORDER ; SCALE ; SEVERITY
资助项目National Natural Science Foundation of China[81673737] ; Beijing Natural Science Foundation[7172063] ; Beijing Administration of Traditional Chinese Medicine[JJ2018-51] ; Beijing Municipal Administration of Hospitals Incubating Program[PZ2017024] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
WOS研究方向Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000518961000001
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Administration of Traditional Chinese Medicine ; Beijing Municipal Administration of Hospitals Incubating Program ; Beijing Health System Training Program for High Level Technique Talents
源URL[http://ir.psych.ac.cn/handle/311026/31374]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Li, Li
作者单位1.Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing, Peoples R China
5.Your Hlth & Wellness Int Med Clin, Beijing, Peoples R China
6.Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yi,Zhao, Jingjie,Wang, Yongzhi,et al. Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:9.
APA Du, Yi.,Zhao, Jingjie.,Wang, Yongzhi.,Han, Yu.,Deng, Ligang.,...&Li, Li.(2020).Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,9.
MLA Du, Yi,et al."Brain Functional Differences in Drug-Naive Major Depression with Anxiety Patients of Different Traditional Chinese Medicine Syndrome Patterns: A Resting-State fMRI Study".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):9.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。