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Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain

文献类型：期刊论文

作者Wang, Ting1; Lian, Zhiyun2; Wu, Xi1; Kong, Yazhuo3; Zhou, Hongyu2; Wei, Min1
刊名MULTIPLE SCLEROSIS AND RELATED DISORDERS
出版日期2020
卷号37页码:6
关键词Neuromyelitis optica Neuropathic pain Voxel-based morphometry Magnetic resonance imaging
ISSN号2211-0348
DOI10.1016/j.msard.2019.101432
通讯作者Zhou, Hongyu(zhouhy@scu.edu.cn) ; Wei, Min(weimin@cuit.edu.cn)
英文摘要Neuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. Pain is one of the most typical symptom in NMO. However, few studies have been conducted to examine the neuropathic pain mechanism of NMO patients or gender-specific effects using magnetic resonance imaging technique. A total of 38 female patients with NMO, 28 with pain (NMOWP) and 10 without pain (NMOWoP), were classified using the Brief Pain Inventory (BPI); 22 healthy females were also recruited. We used the FSL Image Registration and Segmentation Toolbox (FIRST) for subcortical region volumes quantifications, and voxel-based morphometry analysis for cortical gray matter (GM) volume, to examine the brain morphology in NMOWP patients. In addition, correlation test between structural measurements of NMO patients and clinical indexes was also performed. The results showed: 1) no significant differences in cortical GM density between the NMOWP and NMOWoP groups; 2) significantly smaller hippocampus and pallidum volumes in the NMOWP group compared with the NMOWoP group; 3) significant negative correlation between the average BPI and volumes of the accumbens nucleus and thalamus in NMO patients. These results revealed that structural abnormality exists in NMO female patients who have pain, with significant implications for our understanding of the brain morphology in NMO patients with pain.
WOS关键词QUALITY-OF-LIFE ; MULTIPLE-SCLEROSIS ; DIAGNOSTIC-CRITERIA ; BRAIN ABNORMALITIES ; SPECTRUM DISORDER ; THALAMIC NEURONS ; MOTOR CORTEX ; MRI ; PROJECTION ; INPUT
资助项目National Natural Science Foundation[61806029] ; Chengdu University of Information Engineering Research Fund[KYTZ201719] ; Project of Sichuan Provincial Education Hall[18ZA0089] ; Project of Sichuan Provincial Education Hall[2018Z065]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000521647200013
出版者ELSEVIER SCI LTD
资助机构National Natural Science Foundation ; Chengdu University of Information Engineering Research Fund ; Project of Sichuan Provincial Education Hall
源URL[http://ir.psych.ac.cn/handle/311026/31494]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Zhou, Hongyu; Wei, Min
作者单位1.Chengdu Univ Informat Technol, Dept Comp Sci, Chengdu, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Ting,Lian, Zhiyun,Wu, Xi,et al. Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS,2020,37:6.
APA Wang, Ting,Lian, Zhiyun,Wu, Xi,Kong, Yazhuo,Zhou, Hongyu,&Wei, Min.(2020).Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain.MULTIPLE SCLEROSIS AND RELATED DISORDERS,37,6.
MLA Wang, Ting,et al."Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain".MULTIPLE SCLEROSIS AND RELATED DISORDERS 37(2020):6.

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来源：心理研究所

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