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Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers

文献类型：期刊论文

作者Shi, Jun-Yan1,2,3; Wang, Ping1,5; Wang, Bin-Hong2,3; Xu, Yong4; Chen, Xiao1,5; Li, Hui-Jie1,5
刊名NEUROSCIENCE
出版日期2020-06-01
卷号436页码:74-81
ISSN号0306-4522
关键词mild cognitive impairment apolipoprotein E connectivity fMRI
DOI10.1016/j.neuroscience.2020.04.011
通讯作者Li, Hui-Jie(lihj@psych.ac.cn)
英文摘要Individuals with mild cognitive impairment (MCI) are regarded as being at high risk of developing Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is a well-established genetic risk factor for developing AD. In the present study, by using voxel-mirrored homotopic connectivity (VMHC), we aimed to explore the potential functional disruptions in MCI APOE-epsilon 4 carriers. Resting-state functional magnetic resonance imaging was performed in 35 MCI APOE-epsilon 4 carriers (27 APOE-epsilon 3 epsilon 4, 8 APOE-epsilon 4 epsilon 4) and 42 MCI APOE-epsilon 4 noncarriers (APOE-epsilon 3 epsilon 3). VMHC was employed to investigate the alterations in functional connectivity in MCI APOE-epsilon 4 carriers. We further investigated the seed-based functional connectivity between the VMHC values of altered regions and other brain regions in the two groups. The results showed that MCI APOE-epsilon 4 carriers presented increased VMHC in the inferior frontal gyrus/insula and middle frontal gyrus/superior frontal gyrus in comparison with noncarriers. We found that MCI APOE-epsilon 4 carriers showed increased functional connectivity between the seed regions (bilateral inferior frontal gyri/insula and bilateral middle frontal gyri/superior frontal gyri) and broad brain areas, including the frontal, temporal, parietal, and cerebellar regions. Our findings provide neuroimaging evidence for the modulation of the APOE genotype on the neurodegenerative disease phenotype and may be potentially important for monitoring disease progression in double-high-risk populations of AD. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS关键词APOLIPOPROTEIN-E EPSILON-4 ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; SYSTEMS NEUROSCIENCE ; YOUNG CARRIERS ; APOE GENOTYPE ; ALLELE ; ASSOCIATION ; VOLUME
资助项目National Natural Science Foundation of China[31871143] ; Chinese Academy of Sciences Youth Innovation Promotion Association, China[2016084]
WOS研究方向Neurosciences & Neurology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000536491900006
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences Youth Innovation Promotion Association, China
源URL[http://ir.psych.ac.cn/handle/311026/31964]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Li, Hui-Jie
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Shanxi Mental Hlth Ctr, Dept Med Psychol, Taiyuan 030000, Peoples R China
3.Psychiat Hosp Taiyuan City, Taiyuan 030000, Peoples R China
4.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,et al. Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers[J]. NEUROSCIENCE,2020,436:74-81.
APA Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,Xu, Yong,Chen, Xiao,&Li, Hui-Jie.(2020).Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers.NEUROSCIENCE,436,74-81.
MLA Shi, Jun-Yan,et al."Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers".NEUROSCIENCE 436(2020):74-81.

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来源：心理研究所

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