Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus
文献类型：期刊论文
| 作者 | Liu, Jian-Wen1,2; Huo, Zong-Qing2; Zhao, Qian2; Hao, Xiao-Jiang2 ; He, Hong-Ping1; Zhang, Yu2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 138页码:7 |
| 关键词 | Melodinus tenuicaudatus Monoterpenoid indole alkaloids Melotenuines A-E Aspidosperma-meloscandonine type |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2019.104347 |
| 通讯作者 | He, Hong-Ping(hehongping@yahoo.com) ; Zhang, Yu(zhangyu@mail.kib.ac.cn) |
| 英文摘要 | Five new monoterpenoid indole alkaloids, melotenuines A-E (1-5), along with 18 known indole alkaloids, were isolated from the twigs and leaves of Melodinus tenuicaudatus. The structures of the new alkaloids were determined by a combination of MS, NMR and ECD analysis. Melotenuine A (1) represents the first example of aspidosperma-meloscandonine type bisindole alkaloids characterized by a methylene bridge between the two monomers, while melotenuine B (2) possessed a rare eburnamine-melsocandonine skeleton. All of the new indole alkaloids were evaluated for in vitro cytotoxicities against five human cancer cell lines. Among them, alkaloid 4 showed specific cytotoxicity against HL-60 cell line with IC 50 value (5.15 +/- 0.16 mu M) comparable with that of positive control. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000498290700022 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70469]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | He, Hong-Ping; Zhang, Yu |
| 作者单位 | 1.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,et al. Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus[J]. FITOTERAPIA,2019,138:7. |
| APA | Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,Hao, Xiao-Jiang,He, Hong-Ping,&Zhang, Yu.(2019).Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus.FITOTERAPIA,138,7. |
| MLA | Liu, Jian-Wen,et al."Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus".FITOTERAPIA 138(2019):7. |
入库方式： OAI收割
来源：昆明植物研究所
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