Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces
文献类型：期刊论文
| 作者 | Wang Lei3,4,5 ; Wang Li1,4,5; Zhou Zhi1,2,4,5; Wang Yong-Jiang1,4,5; Huang Jian-Ping4,5; Ma Ya-Tuan3; Liu Yang2; Huang Sheng-Xiong4,5
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2019-12-01 |
| 卷号 | 17期号:12页码:982-987 |
| 关键词 | Streptomyces Angucyclinones Benz[a]anthracenes Natural products Immunosuppressive activity |
| ISSN号 | 2095-6975 |
| 通讯作者 | Huang Sheng-Xiong(sxhuang@mail.kib.ac.cn) |
| 英文摘要 | Cangumycins A-F (1-6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC50 8.1 and 2.7 mu mol.L-1, respectively) against human T cell proliferation at a non-cytotoxic concentration. |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000504330400016 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70556]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Huang Sheng-Xiong |
| 作者单位 | 1.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 2.Chengdu Med Coll, Res Ctr, Chengdu 610500, Sichuan, Peoples R China 3.Northwest Agr & Forestry Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Lei,Wang Li,Zhou Zhi,et al. Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):982-987. |
| APA | Wang Lei.,Wang Li.,Zhou Zhi.,Wang Yong-Jiang.,Huang Jian-Ping.,...&Huang Sheng-Xiong.(2019).Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),982-987. |
| MLA | Wang Lei,et al."Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):982-987. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。