Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum
文献类型：期刊论文
| 作者 | Dong, Jinrun1; Yue, Grace Gar-Lee2,3; Lee, Julia Kin-Ming2,3; Lau, Clara Bik-San2,3; Qiu, Minghua1
|
| 刊名 | MEDICINAL CHEMISTRY RESEARCH
 |
| 出版日期 | 2020-01-17 |
| 页码 | 7 |
| 关键词 | Cynanchum otophyllum Neurotrophic activity Cytotoxicity Colon cancer cells |
| ISSN号 | 1054-2523 |
| DOI | 10.1007/s00044-020-02506-7 |
| 通讯作者 | Lau, Clara Bik-San(claralau@cuhk.edu.hk) ; Qiu, Minghua(mhchiu@mail.kib.ac.cn) |
| 英文摘要 | Cynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-beta-cymaropyranoside (1), caudatin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000507790700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70628]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Lau, Clara Bik-San; Qiu, Minghua |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum[J]. MEDICINAL CHEMISTRY RESEARCH,2020:7. |
| APA | Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,Lau, Clara Bik-San,&Qiu, Minghua.(2020).Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum.MEDICINAL CHEMISTRY RESEARCH,7. |
| MLA | Dong, Jinrun,et al."Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum".MEDICINAL CHEMISTRY RESEARCH (2020):7. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。