Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels
文献类型：期刊论文
| 作者 | Xin, Ying1,3; Xu, Min3; Wang, Ya-Feng4; Zheng, Xiao-Hong3; Zhu, Hong-Tao2,3; Wang, Dong2,3 ; Yang, Chong-Ren3; Zhang, Ying-Jun2,3
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| 刊名 | NATURAL PRODUCT RESEARCH
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| 出版日期 | 2020-01-24 |
| 页码 | 8 |
| 关键词 | Phyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2020.1712387 |
| 通讯作者 | Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn) |
| 英文摘要 | A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000509172800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70649]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhang, Ying-Jun |
| 作者单位 | 1.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 4.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xin, Ying,Xu, Min,Wang, Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2020:8. |
| APA | Xin, Ying.,Xu, Min.,Wang, Ya-Feng.,Zheng, Xiao-Hong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,8. |
| MLA | Xin, Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH (2020):8. |
入库方式： OAI收割
来源：昆明植物研究所
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