Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides
文献类型：期刊论文
| 作者 | Li, Penghua1,2 ; He, Haiqing1; Zhang, Yunqin1; Yang, Rui1; Xu, Lili1; Chen, Zixi1; Huang, Yingying1; Bao, Limei1; Xiao, Guozhi1
|
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2020-01-21 |
| 卷号 | 11期号:1页码:10 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-020-14295-z |
| 通讯作者 | Xiao, Guozhi(xiaoguozhi@mail.kib.ac.cn) |
| 英文摘要 | Both of O-glycosides and nucleosides are important biomolecules with crucial rules in numerous biological processes. Chemical synthesis is an efficient and scalable method to produce well-defined and pure carbohydrate-containing molecules for deciphering their functions and developing therapeutic agents. However, the development of glycosylation methods for efficient synthesis of both O-glycosides and nucleosides is one of the long-standing challenges in chemistry. Here, we report a highly efficient and versatile glycosylation method for efficient synthesis of both O-glycosides and nucleosides, which uses glycosyl ortho-(1-phenylvinyl)benzoates as donors. This glycosylation protocol enjoys the various features, including readily prepared and stable donors, cheap and readily available promoters, mild reaction conditions, good to excellent yields, and broad substrate scopes. In particular, the applications of the current glycosylation protocol are demonstrated by one-pot synthesis of several bioactive oligosaccharides and highly efficient synthesis of nucleosides drugs capecitabine, galocitabine and doxifluridine. |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000511940400009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70843]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Xiao, Guozhi |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Univ Chinese Acad Sci, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Penghua,He, Haiqing,Zhang, Yunqin,et al. Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides[J]. NATURE COMMUNICATIONS,2020,11(1):10. |
| APA | Li, Penghua.,He, Haiqing.,Zhang, Yunqin.,Yang, Rui.,Xu, Lili.,...&Xiao, Guozhi.(2020).Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides.NATURE COMMUNICATIONS,11(1),10. |
| MLA | Li, Penghua,et al."Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides".NATURE COMMUNICATIONS 11.1(2020):10. |
入库方式： OAI收割
来源：昆明植物研究所
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