Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces
文献类型：期刊论文
| 作者 | Yang, Feng-Xian1,2; Huang, Jian-Ping1; Liu, Zhixiang3; Wang, Zhiyan1,2; Yang, Jing1 ; Tang, Jun1,2; Yu, Zhiyin1; Yan, Yijun1; Kai, Guoyin3; Huang, Sheng-Xiong1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2020 |
| 卷号 | 83期号:1页码:111-117 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b00903 |
| 通讯作者 | Kai, Guoyin(kaiguoyin@163.com) ; Huang, Sheng-Xiong(sxhuang@mail.kib.ac.cn) |
| 英文摘要 | Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (1-7), together with three known congeners, 8-10, were isolated from culture broth of the soil-derived Streptomyces sp. KIB-H1471. Their structures were elucidated by. using 1D and 2D NMR analyses in combination with HRESIMS data. The absolute configurations of 1-9 were determined by chemical conversion and comparison of circular dichroism spectra and confirmed for 1 by single-crystal X-ray crystallography. Compounds 6 and 7 have a unique gamma-pyrone-like ring on one side chain. Compounds 2 and 6 inhibited human T cell proliferation with IC50 values of 14.3 and 12.5 mu M, respectively, without obvious cytotoxicity for naive human T cells. Compounds 3 and 6 could weakly enhance insulin-stimulated glucose uptake. |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000510076700015 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70889]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Kai, Guoyin; Huang, Sheng-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Zhejiang Chinese Med Univ, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Feng-Xian,Huang, Jian-Ping,Liu, Zhixiang,et al. Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(1):111-117. |
| APA | Yang, Feng-Xian.,Huang, Jian-Ping.,Liu, Zhixiang.,Wang, Zhiyan.,Yang, Jing.,...&Huang, Sheng-Xiong.(2020).Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,83(1),111-117. |
| MLA | Yang, Feng-Xian,et al."Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 83.1(2020):111-117. |
入库方式： OAI收割
来源：昆明植物研究所
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