中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明植物研究所
  3. 中国科学院昆明植物研究所
  4. 植物化学与西部植物资源持续利用国家重点实验室
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1

文献类型：期刊论文

作者Yang, Xiao-Nan3,5; Wang, Yi-Kun2,5; Zhu, Xu2,5; Xiao, Xue-Rong5; Dai, Man-Yun2,5; Zhang, Ting2,5; Qu, Yan5; Yang, Xiu-Wei1; Qin, Hong-Bo5; Gonzalez, Frank J.4
刊名CHEMICAL RESEARCH IN TOXICOLOGY
出版日期2019-10-01
卷号32期号:10页码:1965-1976
ISSN号0893-228X
DOI10.1021/acs.chemrestox.9b00112
通讯作者Li, Fei(lifeib@mail.kib.ac.cn)
英文摘要Elemicin is a constituent of natural aromatic phenyl-propanoids present in many herbs and spices. However, its potential to cause toxicity remains unclear. To examine the potential toxicity and associated mechanism, elemicin was administered to mice for 3 weeks and serum metabolites were examined. Enlarged livers were observed in elemicin-treated mice, which were accompanied by lower ratios of unsaturated- and saturated-lysophosphatidylcholines in plasma, and inhibition of stearoyl-CoA desaturase 1 (Scd1) mRNA expression in liver. Administration of the unsaturated fatty acid oleic acid reduced the toxicity of 1'-hydroxylelemicin, the primary oxidative metabolite of elemicin, while treatment with the SCD1 inhibitor A939572 potentiated its toxicity. Furthermore, the in vitro use of recombinant human CYPs and chemical inhibition of CYPs in human liver microsomes revealed that 0 CYP1A1 and CYP1A2 were the primary CYPs responsible for elemicin bioactivation. Notably, the CYP1A2 inhibitor alpha-naphthoflavone could attenuate the susceptibility of mice to elemicin-induced hepatomegaly. This study revealed that metabolic activation of elemicin leads to SCD1 inhibition in liver, suggesting that upregulation of SCD1 may serve as potential intervention strategy for elemicin-induced toxicity.
WOS研究方向Pharmacology & Pharmacy ; Chemistry ; Toxicology
语种英语
WOS记录号WOS:000492118000007
源URL[http://ir.kib.ac.cn/handle/151853/70932]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li, Fei
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangxi Bot Garden Med Plant, Guangxi Key Lab Med Resources Protect & Genet Imp, Nanning 530023, Peoples R China
4.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
5.Chinese Acad Sci, Kunming Inst Bot, States Key Lab Phytochem & Plant Resources West C, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Xiao-Nan,Wang, Yi-Kun,Zhu, Xu,et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2019,32(10):1965-1976.
APA Yang, Xiao-Nan.,Wang, Yi-Kun.,Zhu, Xu.,Xiao, Xue-Rong.,Dai, Man-Yun.,...&Li, Fei.(2019).Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1.CHEMICAL RESEARCH IN TOXICOLOGY,32(10),1965-1976.
MLA Yang, Xiao-Nan,et al."Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1".CHEMICAL RESEARCH IN TOXICOLOGY 32.10(2019):1965-1976.

入库方式： OAI收割

来源：昆明植物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。