Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine
文献类型：期刊论文
| 作者 | Yao, Jian-Neng1,2; Liang, Xiao2 ; Wei, Kun2; Yang, Yu-Rong2
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-10-18 |
| 卷号 | 21期号:20页码:8485-8487 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b03319 |
| 通讯作者 | Yang, Yu-Rong(yangyurong@mail.kib.ac.cn) |
| 英文摘要 | A catalytic, enantioselective formal synthesis of monoterpene indole alkaloid (-)-alstoscholarine is described. The synthesis employs an Ir-amine dual catalyzed asymmetric allylation of aldehyde 8 with 3-indolyl vinyl carbinol derivative 7 to furnish chiral aldehyde 6 as a key asymmetric step. Other key reactions include the construction of the 2-ketopyrrole moiety by Nicolaou's method and Tf2O promoted Pictet Spengler cyclization to access Zhu's intermediate 3. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000492114600070 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/70973]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Yang, Yu-Rong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Jian-Neng,Liang, Xiao,Wei, Kun,et al. Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine[J]. ORGANIC LETTERS,2019,21(20):8485-8487. |
| APA | Yao, Jian-Neng,Liang, Xiao,Wei, Kun,&Yang, Yu-Rong.(2019).Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine.ORGANIC LETTERS,21(20),8485-8487. |
| MLA | Yao, Jian-Neng,et al."Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine".ORGANIC LETTERS 21.20(2019):8485-8487. |
入库方式： OAI收割
来源：昆明植物研究所
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