Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
文献类型：期刊论文
| 作者 | Wang,Zengyuan; Jiang,Mengjun; Khan,Afsar; Cai,Shengbao; Li,Xiaonian; Liu,Junqiu; Kai,Guoyin; Zhao,Tianrui; Cheng,Guiguang; Cao,Jianxin |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2019 |
| 卷号 | 168页码:UNSP 112127 |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2019.112127 |
| 英文摘要 | Five undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production. |
| WOS记录号 | WOS:000496894000010 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/71103]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang,Zengyuan,Jiang,Mengjun,Khan,Afsar,et al. Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2019,168:UNSP 112127. |
| APA | Wang,Zengyuan.,Jiang,Mengjun.,Khan,Afsar.,Cai,Shengbao.,Li,Xiaonian.,...&Cao,Jianxin.(2019).Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.PHYTOCHEMISTRY,168,UNSP 112127. |
| MLA | Wang,Zengyuan,et al."Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity".PHYTOCHEMISTRY 168(2019):UNSP 112127. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。