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  5. 神经计算及脑机交互
Reorganization of rich-clubs in functional brain networks during propofol-induced unconsciousness and natural sleep

文献类型：期刊论文

作者Wang Shengpei1,6,7; Yun, Li2; Shuang, Qiu6,7; Zhang Chuncheng6,7; Wang Guyan2; Xian Junfang3; Li, Tianzuo2,4; He Huiguang1,5,6,7
刊名NEUROIMAGE-CLINICAL
出版日期2020
卷号25页码:18
ISSN号2213-1582
关键词Resting-state functional magnetic resonance images (rs-fMRI) Brain network Rich-club organization Propofol-induced sedation Natural sleep
DOI10.1016/j.nicl.2020.102188
通讯作者Li, Tianzuo(trmzltz@126.com) ; He Huiguang(huiguang.he@ia.ac.cn)
英文摘要Background: General anesthesia (GA) provides an invaluable experimental tool to understand the essential neural mechanisms underlying consciousness. Previous neuroimaging studies have shown the functional integration and segregation of brain functional networks during anesthetic-induced alteration of consciousness. However, the organization pattern of hubs in functional brain networks remains unclear. Moreover, comparisons with the well-characterized physiological unconsciousness can help us understand the neural mechanisms of anesthetic-induced unconsciousness. Methods: Resting-state functional magnetic resonance imaging was performed during wakefulness, mild propofol-induced sedation (m-PIS), and deep PIS (d-PIS) with clinical unconsciousness on 8 healthy volunteers and wakefulness and natural sleep on 9 age- and sex-matched healthy volunteers. Large-scale functional brain networks of each volunteer were constructed based on 160 regions of interest. Then, rich-club organizations in brain functional networks and nodal properties (nodal strength and efficiency) were assessed and analyzed among the different states and groups. Results: Rich-clubs in the functional brain networks were reorganized during alteration of consciousness induced by propofol. Firstly, rich-club nodes were switched from the posterior cingulate cortex (PCC), angular gyrus, and anterior and middle insula to the inferior parietal lobule (IPL), inferior parietal sulcus (IPS), and cerebellum. When sedation was deepened to unconsciousness, the rich-club nodes were switched to the occipital and angular gyrus. These results suggest that the rich-club nodes were switched among the high-order cognitive function networks (default mode network [DMN] and fronto-parietal network [FPN]), sensory networks (occipital network [ON]), and cerebellum network (CN) from consciousness (wakefulness) to propofol-induced unconsciousness. At the same time, compared with wakefulness, local connections were switched to rich-club connections during propofol-induced unconsciousness, suggesting a strengthening of the overall information commutation of networks. Nodal efficiency of the anterior and middle insula and ventral frontal cortex was significantly decreased. Additionally, from wakefulness to natural sleep, a similar pattern of rich-club reorganization with propofol-induced unconsciousness was observed: rich-club nodes were switched from the DMN (including precuneus and PCC) to the sensorimotor network (SMN, including part of the frontal and temporal gyrus). Compared with natural sleep, nodal efficiency of the insula, frontal gyrus, PCC, and cerebellum significantly decreased during propofol-induced unconsciousness. Conclusions: Our study demonstrated that the rich-club reorganization in functional brain networks is characterized by switching of rich-club nodes between the high-order cognitive and sensory and motor networks during propofol-induced alteration of consciousness and natural sleep. These findings will help understand the common neurological mechanism of pharmacological and physiological unconsciousness.
WOS关键词DEFAULT-MODE NETWORK ; RESTING-STATE NETWORKS ; GLOBAL SIGNAL REGRESSION ; GENERAL-ANESTHESIA ; INTRINSIC CONNECTIVITY ; TOPOLOGICAL ORGANIZATION ; FRONTOPARIETAL NETWORK ; CONSCIOUS SEDATION ; NEURONAL PATHWAYS ; BASE-LINE
资助项目National Natural Science Foundation of China[61976209] ; National Natural Science Foundation of China[81701785] ; CAS International Collaboration Key Project ; Strategic Priority Research Program of CAS[XDB32040200]
WOS研究方向Neurosciences & Neurology
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000519535200076
资助机构National Natural Science Foundation of China ; CAS International Collaboration Key Project ; Strategic Priority Research Program of CAS
源URL[http://ir.ia.ac.cn/handle/173211/38600]  
专题类脑智能研究中心_神经计算及脑机交互
通讯作者Li, Tianzuo; He Huiguang
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesia, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, 10 Tieyi Rd,Yangfangdian Rd, Beijing 100038, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang Shengpei,Yun, Li,Shuang, Qiu,et al. Reorganization of rich-clubs in functional brain networks during propofol-induced unconsciousness and natural sleep[J]. NEUROIMAGE-CLINICAL,2020,25:18.
APA Wang Shengpei.,Yun, Li.,Shuang, Qiu.,Zhang Chuncheng.,Wang Guyan.,...&He Huiguang.(2020).Reorganization of rich-clubs in functional brain networks during propofol-induced unconsciousness and natural sleep.NEUROIMAGE-CLINICAL,25,18.
MLA Wang Shengpei,et al."Reorganization of rich-clubs in functional brain networks during propofol-induced unconsciousness and natural sleep".NEUROIMAGE-CLINICAL 25(2020):18.

入库方式： OAI收割

来源：自动化研究所

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