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Heterogeneity of metastatic gastrointestinal stromal tumor on texture analysis: DWI texture as potential biomarker of overall survival

文献类型：期刊论文

作者Fu, Jia1,2; Fang, Meng-jie3,4; Dong, Di3,4; Li, Jian5; Sun, Ying-shi1; Tian, Jie3,4; Tang, Lei1
刊名EUROPEAN JOURNAL OF RADIOLOGY
出版日期2020-04-01
卷号125页码:6
关键词Gastrointestinal stromal tumor Prognosis Magnetic resonance imaging Texture analysis
ISSN号0720-048X
DOI10.1016/j.ejrad.2020.108825
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Tang, Lei(tangl@bjcancer.org)
英文摘要Purpose: To determine if texture features of diffusion weighted imaging (DWI) on MRI of metastatic gastrointestinal stromal tumor (mGIST) have correlation with overall survival (OS). Method: Fifty-one GIST patients with metastatic lesions who received imatinib targeted therapy were included. Texture features of the largest metastatic lesion were analyzed using inhouse software. Three types of texture features were assessed: fractal features, gray-level co-occurrence matrix (GLCM) features, and gray-level runlength matrix (GLRLM) features. The features were extracted from the regions of interest (ROIs) on T2-weighted imaging (T2WI), DWI and apparent diffusion coefficient (ADC) maps. Histogram analysis was performed on ADC maps. Patients were followed up until death. Kaplan-Meier analysis was performed to determine the correlation of texture features with OS. The curves of the high- and low-risk groups were compared using log-rank test. The prognostic efficacy of the predictors was assessed by calculating the concordance probability. Results: The median survival time was 43.5 months (range, 3.97-120.90 m). Four DWI and three ADC texture features showed significant correlation with OS on univariate analysis (p < 0.05). DWI_L_GLCM_maximum_probability [hazard ratio (HR): 2.062 (1.357-3.131)], ADC_H_GLRLM_mean [HR: 2.174 (1.457-3.244)], and ADC_O_GLCM_cluster_shade [HR: 1.882 (1.324-2.674)] were identified as representative prognostic indicators. The optimum threshold levels for these three features were 1.19 x 100, 1.71 x 10 and 2.19 x 0.1, respectively. Neither histogram analysis values nor fractal features revealed significant correlation with survival status (p > 0.05). Conclusions: Texture features of the mGIST on DWI exhibited correlation with overall survival. High-grade heterogeneity was associated with poor prognosis.
WOS关键词IMATINIB ; SURGERY ; IMAGES ; RISK
资助项目National Key R&D Program of China[2018YFC0910700] ; National Key R&D Program of China[2017YFC1309101] ; National Key R&D Program of China[2017YFC1309104] ; Beijing Natural Science Foundation[Z180001] ; Beijing Natural Science Foundation[L182061] ; National Natural Science Foundation of China[91959130] ; National Natural Science Foundation of China[81971776] ; National Natural Science Foundation of China[81771924]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000522392200017
出版者ELSEVIER IRELAND LTD
资助机构National Key R&D Program of China ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/38716]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Tang, Lei
作者单位1.Peking Univ, Radiol Dept, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Civil Aviat Gen Hosp, Dept Radiol, 1 Chaoyang Rd, Beijing 100123, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Peking Univ, Dept Gastroenterol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Canc Hosp & Inst, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Jia,Fang, Meng-jie,Dong, Di,et al. Heterogeneity of metastatic gastrointestinal stromal tumor on texture analysis: DWI texture as potential biomarker of overall survival[J]. EUROPEAN JOURNAL OF RADIOLOGY,2020,125:6.
APA Fu, Jia.,Fang, Meng-jie.,Dong, Di.,Li, Jian.,Sun, Ying-shi.,...&Tang, Lei.(2020).Heterogeneity of metastatic gastrointestinal stromal tumor on texture analysis: DWI texture as potential biomarker of overall survival.EUROPEAN JOURNAL OF RADIOLOGY,125,6.
MLA Fu, Jia,et al."Heterogeneity of metastatic gastrointestinal stromal tumor on texture analysis: DWI texture as potential biomarker of overall survival".EUROPEAN JOURNAL OF RADIOLOGY 125(2020):6.

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来源：自动化研究所

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