Mismatch of cognition and neural networks in asymptomatic middle cerebral artery steno-occlusive disease
文献类型：期刊论文
| 作者 | Liu, C-Y3; Yan, S.2 ; Hou, B.2; Li, M-L2; Gao, S.3; Li, A.1,4; Liu, B.1,4; Xu, W-H3
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| 刊名 | EUROPEAN JOURNAL OF NEUROLOGY
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| 出版日期 | 2020-04-03 |
| 页码 | 4 |
| ISSN号 | 1351-5101 |
| 关键词 | cognition functional magnetic resonance imaging middle cerebral artery steno-occlusion |
| DOI | 10.1111/ene.14210 |
| 通讯作者 | Xu, W-H(xuwh@pumch.cn) |
| 英文摘要 | Background and purpose The role of intracranial steno-occlusive disease in cognitive impairment and dementia is unclear and has not been well studied. Methods A total of 32 consecutive patients (13 males, aged 54 +/- 12 years) with asymptomatic steno-occlusive middle cerebral artery (MCA) disease, defined as >70% stenosis on maximum intensity projection images or a complete signal loss of MCA trunk on magnetic resonance angiography, and 20 age- and education-matched normal controls (12 males, 60 +/- 8 years old) were compared for neuropsychological performance, gray matter volume and neural network analysis. Results The patient group did not show a significant decrease in gray matter volume or cognitive tests except for their performance on the grooved pegboard test. However, graph analysis of resting-state functional magnetic resonance imaging showed significant decreases in network strength, global efficiency and the clustering coefficient, as well as a longer characteristic path length (P < 0.05). The diffusive decrease pattern was particularly located in interhemispheric connectivity and there was no compensatory hyperconnectivity in any brain regions. Conclusion In asymptomatic steno-occlusive MCA disease, cognition and neural network changes are mismatched and have underlying pathophysiological mechanisms that are different from those of neurodegenerative disease. |
| WOS关键词 | RISK |
| 资助项目 | Program for National Natural Science Foundation of China[81471207] ; Program for National Natural Science Foundation of China[81671370] ; Peking Union Medical College Hospital |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000523258200001 |
| 资助机构 | Program for National Natural Science Foundation of China ; Peking Union Medical College Hospital |
| 源URL | [http://ir.ia.ac.cn/handle/173211/38776]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Xu, W-H |
| 作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, C-Y,Yan, S.,Hou, B.,et al. Mismatch of cognition and neural networks in asymptomatic middle cerebral artery steno-occlusive disease[J]. EUROPEAN JOURNAL OF NEUROLOGY,2020:4. |
| APA | Liu, C-Y.,Yan, S..,Hou, B..,Li, M-L.,Gao, S..,...&Xu, W-H.(2020).Mismatch of cognition and neural networks in asymptomatic middle cerebral artery steno-occlusive disease.EUROPEAN JOURNAL OF NEUROLOGY,4. |
| MLA | Liu, C-Y,et al."Mismatch of cognition and neural networks in asymptomatic middle cerebral artery steno-occlusive disease".EUROPEAN JOURNAL OF NEUROLOGY (2020):4. |
入库方式： OAI收割
来源：自动化研究所
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