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Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers

文献类型：期刊论文

作者Yin, Pengju2; Zhao, Lei2; Chen, Zezhou2; Jiao, Zhiqiang2; Shi, Hongyan2; Hu, Bo2; Yuan, Shifang3; Tian, Jie1,2
刊名SOFT MATTER
出版日期2020-03-28
卷号16期号:12页码:3096-3105
ISSN号1744-683X
DOI10.1039/d0sm00084a
通讯作者Hu, Bo(bohu@xidian.edu.cn) ; Yuan, Shifang(shifangy@fmmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Inertial focusing of particles in serpentine microfluidic chips has been studied over the past decade. Here, a study to investigate the particle inertial focusing in 3D-printed serpentine microfluidic chips was conducted by simulation and practice. A test model was designed and printed using four commercial 3D-printers. Commercial inkjet 3D-printers have shown the best printing channel resolution of up to 0.1 mm. The force analysis of particle inertial focusing in 3D-printed microfluidic chips with large cross-sectional channels was discussed. Important parameters such as the channel curvature and flow velocity were studied by simulation. The optimal channel curvature and flow velocity are 5.9 mm and 480 mu L min(-1) (Re: 29.8 and De: 4.49) in the 3D-printed microfluidic chips with 0.2 mm x 0.4 mm cross-sectional channels. Under these optimal conditions, particles were well focused in the middle of the channel. Furthermore, two kinds of cancer cells were focused in these 3D-printed serpentine microfluidic chips under the optimal conditions. We envision that this improved study would provide helpful insights into simulating particle inertial focusing in 3D-printed microfluidic chips and promoting 3D-printed microfluidic chips to commercial production.
WOS关键词POISEUILLE FLOW ; CANCER-CELLS ; SEPARATION ; DEVICES ; FUNDAMENTALS ; FABRICATION
资助项目National Key Research and Development Program of China[2016YFC0102000] ; National Key Research and Development Program of China[2017YFA0205202] ; National Natural Science Foundation of China[81772011] ; National Natural Science Foundation of China[31800714] ; 100 Talents Project of Shaanxi Province, China[SXBR9181] ; Natural Science Basic Research Plan in Shaanxi Province of China[2018JQ3027] ; Fundamental Research Funds for the Central Universities[JC1907] ; Doctoral Students' Short-Term Study Abroad Scholarship Fund of Xidian University
WOS研究方向Chemistry ; Materials Science ; Physics ; Polymer Science
语种英语
WOS记录号WOS:000526925800017
出版者ROYAL SOC CHEMISTRY
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; 100 Talents Project of Shaanxi Province, China ; Natural Science Basic Research Plan in Shaanxi Province of China ; Fundamental Research Funds for the Central Universities ; Doctoral Students' Short-Term Study Abroad Scholarship Fund of Xidian University
源URL[http://ir.ia.ac.cn/handle/173211/39355]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Bo; Yuan, Shifang; Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Lib, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714		 Yin, Pengju,Zhao, Lei,Chen, Zezhou,et al. Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers[J]. SOFT MATTER,2020,16(12):3096-3105.
APA Yin, Pengju.,Zhao, Lei.,Chen, Zezhou.,Jiao, Zhiqiang.,Shi, Hongyan.,...&Tian, Jie.(2020).Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers.SOFT MATTER,16(12),3096-3105.
MLA Yin, Pengju,et al."Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers".SOFT MATTER 16.12(2020):3096-3105.

入库方式： OAI收割

来源：自动化研究所

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