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Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy

文献类型：期刊论文

作者Tao, Qi1,2,3,6; Yang, Yongfeng4,5,7,8; Yu, Hongyan4; Fan, Lingzhong11,12,13; Luan, Shuxin9,10; Zhang, Lei9,10; Zhao, Hua10; Lv, Luxian4,5,7; Jiang, Tianzi8,11,12,13; Song, Xueqin1,2,6
刊名FRONTIERS IN PSYCHIATRY
出版日期2020-04-03
卷号11页码:8
关键词treatment-resistant depression (TRD) transcranial magnetic stimulation (TMS) anatomical connectivity subgenual anterior cingulated cortex (sACC) prefrontal cortex (PFC)
ISSN号1664-0640
DOI10.3389/fpsyt.2020.00236
通讯作者Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Song, Xueqin(fccsongxq@zzu.edu.cn)
英文摘要Objectives Abnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting the sACC as a potentially effective target for therapeutic modulation in cases resistant to conventional treatments (treatment-resistant depression, TRD). We hypothesized that areas in the prefrontal cortex (PFC) with direct fiber connections to the sACC may be particularly effective sites for treatment using transcranial magnetic stimulation (TMS). The aim of this study was to identify PFC sites most strongly connected to the sACC. Methods Two neuroimaging data sets were used to construct anatomic and functional connectivity maps using sACC as the seed region. Data set 1 included magnetic resonance (MR) images from 20 healthy controls and Data set 2 included MR images from 15 TRD patients and 15 additional healthy controls. PFC voxels with maximum values in the mean anatomic connection probability maps were identified as optimal sites for TMS. Results Both right and left PFC contained sites strongly connected to the sACC, but the coordinates (in Montreal Neurological Institute space) of peak anatomic connectivity differed slightly between hemispheres. The left PFC site connected directly to the sACC both anatomically and functionally, while the right PFC site was functionally connected to the posterior cingulate cortex (PCC). Conclusions Both left and right PFC are functionally connected to regions implicated in depression, the sACC and PCC, respectively. These bilateral PFC sites may be effective TMS targets to treat TRD.
WOS关键词DORSOLATERAL PREFRONTAL CORTEX ; DEEP BRAIN-STIMULATION ; TREATMENT-RESISTANT DEPRESSION ; SUBCALLOSAL CINGULATE GYRUS ; CEREBRAL-BLOOD-FLOW ; MAJOR DEPRESSION ; FUNCTIONAL CONNECTIVITY ; EFFICACY ; MOOD ; RTMS
资助项目National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81571318] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Health and Family Planning Commission of Henan Province[201501015] ; Department of Science and Technology of Henan Province[162102410061] ; Department of Science and Technology of Henan Province[2017JQ023] ; School and Hospital Co-incubation Funds[2017-BSTDJJ-04] ; Research Council of Norway[223273]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000528705700001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; Medical Science and Technology Research Project of Henan Province ; Health and Family Planning Commission of Henan Province ; Department of Science and Technology of Henan Province ; School and Hospital Co-incubation Funds ; Research Council of Norway
源URL[http://ir.ia.ac.cn/handle/173211/39371]  
专题自动化研究所_脑网络组研究中心
通讯作者Jiang, Tianzi; Song, Xueqin
作者单位1.Zhengzhou Univ, Biol Psychiat Int Joint Lab Henan, Zhengzhou, Peoples R China
2.Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China
3.Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
4.Xinxiang Med Univ, Henan Mental Hosp, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China
5.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China
6.Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou, Peoples R China
7.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Henan, Peoples R China
8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China
9.Jilin Univ, Dept Psychiat, Bethune Hosp 1, Changchun, Peoples R China
10.Jilin Univ, Coll Basic Med Sci, Dept Physiol, Jilin, Jilin, Peoples R China
推荐引用方式
GB/T 7714		 Tao, Qi,Yang, Yongfeng,Yu, Hongyan,et al. Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy[J]. FRONTIERS IN PSYCHIATRY,2020,11:8.
APA Tao, Qi.,Yang, Yongfeng.,Yu, Hongyan.,Fan, Lingzhong.,Luan, Shuxin.,...&Song, Xueqin.(2020).Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy.FRONTIERS IN PSYCHIATRY,11,8.
MLA Tao, Qi,et al."Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy".FRONTIERS IN PSYCHIATRY 11(2020):8.

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来源：自动化研究所

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