中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A single-cell transcriptomic landscape of primate arterial aging

文献类型:期刊论文

作者Zhang, Weiqi1,2,3,4,5,13; Zhang, Shu6,14; Yan, Pengze2,7; Ren, Jie6,8; Song, Moshi2,5,7; Li, Jingyi2,3,7; Lei, Jinghui1,13; Pan, Huize2,3; Wang, Si2,5,7; Ma, Xibo2,9,10
刊名NATURE COMMUNICATIONS
出版日期2020-05-05
卷号11期号:1页码:13
ISSN号2041-1723
DOI10.1038/s41467-020-15997-0
通讯作者Liu, Guang-Hui(ghliu@ioz.ac.cn) ; Tang, Fuchou(tangfuchou@pku.edu.cn) ; Qu, Jing(qujing@ioz.ac.cn)
英文摘要Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we report a single-cell transcriptomic survey of aortas and coronary arteries in young and old cynomolgus monkeys. Our data define the molecular signatures of specialized arteries and identify eight markers discriminating aortic and coronary vasculatures. Gene network analyses characterize transcriptional landmarks that regulate vascular senility and position FOXO3A, a longevity-associated transcription factor, as a master regulator gene that is downregulated in six subtypes of monkey vascular cells during aging. Targeted inactivation of FOXO3A in human vascular endothelial cells recapitulates the major phenotypic defects observed in aged monkey arteries, verifying FOXO3A loss as a key driver for arterial endothelial aging. Our study provides a critical resource for understanding the principles underlying primate arterial aging and contributes important clues to future treatment of age-associated vascular disorders. Arterial degeneration, closely associated with cardiovascular diseases, is driven by aging-related vascular cell-specific transcriptomics changes. This study provides a single-cell transcriptomic atlas for senile aortic and coronary arteries and underscores FOXO3A-based the transcriptional network in vasoprotection during aging.
WOS关键词ATHEROSCLEROSIS ; EXPRESSION ; ATLAS ; QUANTIFICATION ; RECONSTRUCTION ; INTEGRATION ; MECHANISMS ; REGULATORS ; SIGNATURES ; INFERENCE
资助项目National Key Research and Development Program of China[2017YFA0103304] ; National Key Research and Development Program of China[2017YFA0102802] ; National Key Research and Development Program of China[2018YFA0107203] ; National Key Research and Development Program of China[2018YFC2000400] ; National Key Research and Development Program of China[2018YFC2000100] ; National Key Research and Development Program of China[2016YFA0100902] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16010100] ; National Natural Science Foundation of China[81921006] ; National Natural Science Foundation of China[81625009] ; National Natural Science Foundation of China[91749202] ; National Natural Science Foundation of China[81861168034] ; National Natural Science Foundation of China[31671429] ; National Natural Science Foundation of China[91949209] ; National Natural Science Foundation of China[81671377] ; National Natural Science Foundation of China[91749123] ; National Natural Science Foundation of China[81822018] ; National Natural Science Foundation of China[81870228] ; National Natural Science Foundation of China[81922027] ; National Natural Science Foundation of China[81701388] ; National Natural Science Foundation of China[81801399] ; National Natural Science Foundation of China[81801370] ; Program of Beijing Municipal Science and Technology Commission[Z191100001519005] ; Beijing Natural Science Foundation[Z190019] ; Beijing Municipal Commission of Health and Family Planning[PXM2018_026283_000002] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-221] ; Advanced Innovation Center for Human Brain Protection[3500-1192012] ; K.C. Wong Education Foundation[GJTD-2019-06] ; K.C. Wong Education Foundation[GJTD-2019-08] ; Youth Innovation Promotion Association of CAS ; Young Elite Scientists Sponsorship Program by CAST[2017QNRC001] ; China Postdoctoral Science Foundation[2018M640154] ; State Key Laboratory of Stem Cell and Reproductive Biology ; State Key Laboratory of Membrane Biology ; Beijing Advanced Innovation Center for Genomics (ICG) at Peking University
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000532362000001
资助机构National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Program of Beijing Municipal Science and Technology Commission ; Beijing Natural Science Foundation ; Beijing Municipal Commission of Health and Family Planning ; Key Research Program of the Chinese Academy of Sciences ; Advanced Innovation Center for Human Brain Protection ; K.C. Wong Education Foundation ; Youth Innovation Promotion Association of CAS ; Young Elite Scientists Sponsorship Program by CAST ; China Postdoctoral Science Foundation ; State Key Laboratory of Stem Cell and Reproductive Biology ; State Key Laboratory of Membrane Biology ; Beijing Advanced Innovation Center for Genomics (ICG) at Peking University
源URL[http://ir.ia.ac.cn/handle/173211/39480]  
专题自动化研究所_模式识别国家重点实验室_生物识别与安全技术研究中心
通讯作者Liu, Guang-Hui; Tang, Fuchou; Qu, Jing
作者单位1.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Xuanwu Hosp, Beijing Inst Brain Disorders, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
6.Peking Univ, Biomed Inst Pioneering Invest Via Convergence, Beijing 100871, Peoples R China
7.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
8.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
9.Chinese Acad Sci, Inst Automat, CBSR, Beijing 100190, Peoples R China
10.Chinese Acad Sci, Inst Automat, NLPR, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Weiqi,Zhang, Shu,Yan, Pengze,et al. A single-cell transcriptomic landscape of primate arterial aging[J]. NATURE COMMUNICATIONS,2020,11(1):13.
APA Zhang, Weiqi.,Zhang, Shu.,Yan, Pengze.,Ren, Jie.,Song, Moshi.,...&Qu, Jing.(2020).A single-cell transcriptomic landscape of primate arterial aging.NATURE COMMUNICATIONS,11(1),13.
MLA Zhang, Weiqi,et al."A single-cell transcriptomic landscape of primate arterial aging".NATURE COMMUNICATIONS 11.1(2020):13.

入库方式: OAI收割

来源:自动化研究所

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