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Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging

文献类型：期刊论文

作者Kang, Xiao-wei5,6; Xi, Yi-bin5,6; Liu, Ting-ting1,6; Wang, Ning4,6; Zhu, Yuan-qiang6; Wang, Xing-rui2,6; Guo, Fan3,6
刊名BMC MEDICAL IMAGING
出版日期2020-05-14
卷号20期号:1页码:8
关键词Glioma Magnetic resonance imaging Arterial spin labeling Amide proton transfer Apparent diffusion coefficient
ISSN号1471-2342
DOI10.1186/s12880-020-00450-x
通讯作者Guo, Fan(guofan0602@hotmail.com)
英文摘要Background To investigate the ability of amide proton transfer (APT) weighted magnetic resonance imaging (MRI), arterial spin labeling (ASL), diffusion weighted imaging (DWI) and the combination for differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Methods Twenty-seven patients including nine LGGs and eighteen HGGs underwent conventional, APT, ASL and DWI MRI with a 3.0-T MR scanner. Histogram analyses was performed and quantitative parameters including mean apparent diffusion coefficient (ADC mean), 20th-percentile ADC (ADC 20th), mean APT (APT mean), 90th-percentile APT (APT 90th), relative mean cerebral blood flow (rCBF mean) and relative 90th-percentile CBF (rCBF 90th) were compared between HGGs and LGGs. The diagnostic performance was evaluated with receiver operating characteristic (ROC) analysis of each parameter and their combination. Correlations were analyzed among the MRI parameters and Ki-67. Results The APT values were significantly higher in the HGGs compared to the LGGs (p < 0.005), whereas ADC values were significantly lower in HGGs than LGGs (P < 0.0001). The ADC 20th and APT mean had higher discrimination abilities compared with other single parameters, with the area under the ROC curve (AUC) of 0.877 and 0.840. Adding ADC parameter, the discrimination ability of APT and rCBF significantly improved. The ADC was negatively correlated with the APT and rCBF value, respectively, while APT value was positively correlated with rCBF value. Significant correlations between ADC values and Ki-67 were also observed. Conclusions APT and DWI are valuable in differentiating HGGs from LGGs. The combination of APT, DWI and ASL imaging could improve the ability for discriminating HGGs from LGGs.
WOS关键词TRUE PROGRESSION ; BRAIN-TUMORS ; BLOOD-FLOW ; CONTRAST ; MRI ; COEFFICIENT ; PSEUDOPROGRESSION ; CURVE ; AREA
资助项目National Natural Science Foundation of China[81971594] ; National Natural Science Foundation of China[81400952] ; Natural Science Basic Research Plan in Shaanxi Province of China[2020JM325] ; Subject Boosting Project of Xijing Hospital[XJZT18ML75]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000536233500002
出版者BMC
资助机构National Natural Science Foundation of China ; Natural Science Basic Research Plan in Shaanxi Province of China ; Subject Boosting Project of Xijing Hospital
源URL[http://ir.ia.ac.cn/handle/173211/39518]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Guo, Fan
作者单位1.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Hangzhou, Shaanxi, Peoples R China
2.Northwest Univ, Xian Hosp 3, Dept Radiol, Affiliated Hosp, Xian, Shaanxi, Peoples R China
3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing, Peoples R China
4.Xian Med Coll, Dept Radiol, Affliated Hosp 2, Xian, Shaanxi, Peoples R China
5.Xian Peoples Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China
6.Xijing Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714		 Kang, Xiao-wei,Xi, Yi-bin,Liu, Ting-ting,et al. Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging[J]. BMC MEDICAL IMAGING,2020,20(1):8.
APA Kang, Xiao-wei.,Xi, Yi-bin.,Liu, Ting-ting.,Wang, Ning.,Zhu, Yuan-qiang.,...&Guo, Fan.(2020).Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging.BMC MEDICAL IMAGING,20(1),8.
MLA Kang, Xiao-wei,et al."Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging".BMC MEDICAL IMAGING 20.1(2020):8.

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