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Clothing spiny nanoprobes against the mononuclear phagocyte system clearance in vivo: Photoacoustic diagnosis and photothermal treatment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars

文献类型：期刊论文

作者Huang, Xiazi1,3,4; Shang, Wenting3,4; Deng, Han2,4; Zhou, Yingying1; Cao, Fei1; Fang, Chihua2; Lai, Puxing1; Tian, Jie3,4
刊名APPLIED MATERIALS TODAY
出版日期2020-03-01
卷号18页码:12
关键词Nanoprobe Mononuclear phagocytic system Biomimetic camouflage Photoacoustic imaging Photothermal therapy Liver cancer
ISSN号2352-9407
DOI10.1016/j.apmt.2019.100484
通讯作者Lai, Puxing(puxiang.lai@polyu.edu.hk) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Nanoprobes have been increasingly applied in photoacoustic imaging to improve the diagnosis and treatment of diseases, especially the liver cancer, the fourth leading cause of cancer-related deaths worldwide. The mononuclear phagocytic system (MPS), however, exhibits a crucial impediment to the probe usage, preventing the accumulation of probes within the liver. This, in turn, paralyzes the effort of diagnosis enhancement. To overcome the MPS clearance, a biomimetic probe consisting of erythrocyte membrane-camouflaged gold nanostars was designed and synthesized in this study. The probe possesses broad absorption spectrum, photostability, and photothermal conversion efficiency. More importantly, it yields preeminent immune escape ability, thus being able to escape the MPS clearance and greatly boost the accumulation of probes at the tumor sites with prolonged blood circulation. Experimentally, we demonstrate that the probe can serve as an effective nanoprobe to enhance the in vivo photoacoustic imaging and photothermal treatment of in situ early stage liver tumors in mice. (C) 2019 The Authors. Published by Elsevier Ltd.
WOS关键词CELL MEMBRANE ; POLYMERIC NANOPARTICLES ; TUMOR UPTAKE ; DELIVERY ; MICROSCOPY ; MARKER ; CD47 ; SELF
资助项目National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[81671726] ; National Natural Science Foundation of China[81930048] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205200] ; Hong Kong Research Grant Council[25204416] ; Hong Kong Innovation and Technology Commission[ITS/022/18] ; ShenzhenScience and Technology Innovation Commission[JCYJ20170818104421564]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000530652300028
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; National Key R&D Program of China ; Hong Kong Research Grant Council ; Hong Kong Innovation and Technology Commission ; ShenzhenScience and Technology Innovation Commission
源URL[http://ir.ia.ac.cn/handle/173211/39528]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Lai, Puxing; Tian, Jie
作者单位1.Hong Kong Polytech Univ, Dept Biomed Engn, Hong Kong, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou, Peoples R China
3.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Xiazi,Shang, Wenting,Deng, Han,et al. Clothing spiny nanoprobes against the mononuclear phagocyte system clearance in vivo: Photoacoustic diagnosis and photothermal treatment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars[J]. APPLIED MATERIALS TODAY,2020,18:12.
APA Huang, Xiazi.,Shang, Wenting.,Deng, Han.,Zhou, Yingying.,Cao, Fei.,...&Tian, Jie.(2020).Clothing spiny nanoprobes against the mononuclear phagocyte system clearance in vivo: Photoacoustic diagnosis and photothermal treatment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars.APPLIED MATERIALS TODAY,18,12.
MLA Huang, Xiazi,et al."Clothing spiny nanoprobes against the mononuclear phagocyte system clearance in vivo: Photoacoustic diagnosis and photothermal treatment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars".APPLIED MATERIALS TODAY 18(2020):12.

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