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The relevance of transdiagnostic shared networks to the severity of symptoms and cognitive deficits in schizophrenia: a multimodal brain imaging fusion study

文献类型：期刊论文

作者Qi, Shile3; Bustillo, Juan1; Turner, Jessica A.2,3; Jiang, Rongtao8,9,10; Zhi, Dongmei8,9,10; Fu, Zening3; Deramus, Thomas P.3; Vergara, Victor3; Ma, Xiaohong5,6,7; Yang, Xiao5,6,7
刊名TRANSLATIONAL PSYCHIATRY
出版日期2020-05-18
卷号10期号:1页码:10
ISSN号2158-3188
DOI10.1038/s41398-020-0834-6
通讯作者Calhoun, Vince D.(vcalhoun@gsu.edu) ; Sui, Jing(jing.sui@nlpr.ia.ac.cn)
英文摘要Schizophrenia (SZ) is frequently concurrent with substance use, depressive symptoms, social communication and attention deficits. However, the relationship between common brain networks (e.g., SZ vs. substance use, SZ vs. depression, SZ vs. developmental disorders) with SZ on specific symptoms and cognition is unclear. Symptom scores were used as a reference to guide fMRI-sMRI fusion for SZ (n=94), substance use with drinking (n=313), smoking (n=104), major depressive disorder (MDD, n=260), developmental disorders with autism spectrum disorder (ASD, n=421) and attention-deficit/hyperactivity disorder (ADHD, n=244) respectively. Common brain regions were determined by overlapping the symptom-related components between SZ and these other groups. Correlation between the identified common brain regions and cognition/symptoms in an independent SZ dataset (n=144) was also performed. Results show that (1): substance use was related with cognitive deficits in schizophrenia through gray matter volume (GMV) in anterior cingulate cortex and thalamus; (2) depression was linked to PANSS negative dimensions and reasoning in SZ through a network involving caudate-thalamus-middle/inferior temporal gyrus in GMV; (3) developmental disorders pattern was correlated with poor attention, speed of processing and reasoning in SZ through inferior temporal gyrus in GMV. This study reveals symptom driven transdiagnostic shared networks between SZ and other mental disorders via multi-group data mining, indicating that some potential common underlying brain networks associated with schizophrenia differently with respect to symptoms and cognition. These results have heuristic value and advocate specific approaches to refine available treatment strategies for comorbid conditions in schizophrenia.
WOS关键词MAJOR PSYCHIATRIC-DISORDERS ; ONSET SCHIZOPHRENIA ; COMORBIDITIES ; CONNECTIVITY ; IDENTIFICATION ; CANNABIS ; ALCOHOL ; AUTISM ; VOLUME ; RISK
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS32040100] ; China Natural Science Foundation[61773380] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; National Institute of Health[1R01MH117107] ; National Institute of Health[R01EB020407] ; National Institute of Health[R01MH118695] ; National Institute of Health[1R01EB005846] ; National Institute of Health[1R01MH094524] ; National Institute of Health[P20GM103472] ; National Institute of Health[P30GM122734] ; National Science Foundation[1539067]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000536853000001
出版者NATURE PUBLISHING GROUP
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; China Natural Science Foundation ; Beijing Municipal Science and Technology Commission ; National Institute of Health ; National Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/39532]  
专题自动化研究所_脑网络组研究中心
通讯作者Calhoun, Vince D.; Sui, Jing
作者单位1.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA
2.Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA
3.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA
4.Olin Neuropsychiat Res Ctr, Hartford, CT 06106 USA
5.Sichuan Univ, West China Hosp, Huaxi Brain Res Ctr, Chengdu 610041, Peoples R China
6.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Mental Hlth Ctr, Chengdu 610041, Peoples R China
7.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu 610041, Peoples R China
8.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
9.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
10.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Shile,Bustillo, Juan,Turner, Jessica A.,et al. The relevance of transdiagnostic shared networks to the severity of symptoms and cognitive deficits in schizophrenia: a multimodal brain imaging fusion study[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):10.
APA Qi, Shile.,Bustillo, Juan.,Turner, Jessica A..,Jiang, Rongtao.,Zhi, Dongmei.,...&Sui, Jing.(2020).The relevance of transdiagnostic shared networks to the severity of symptoms and cognitive deficits in schizophrenia: a multimodal brain imaging fusion study.TRANSLATIONAL PSYCHIATRY,10(1),10.
MLA Qi, Shile,et al."The relevance of transdiagnostic shared networks to the severity of symptoms and cognitive deficits in schizophrenia: a multimodal brain imaging fusion study".TRANSLATIONAL PSYCHIATRY 10.1(2020):10.

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