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The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial

文献类型：期刊论文

作者Xing, Yi1,2; Zhu, Zude3; Du, Yifeng4; Zhang, Junjian5; Qu, Qiumin6; Sun, Li7,8; Li, Yang9; Guo, Yanjun10; Peng, Guoping11; Liu, Yong12
刊名JOURNAL OF ALZHEIMERS DISEASE
出版日期2020
卷号75期号:3页码:779-787
关键词Cognitive training mild cognitive impairment non-pharmacological intervention randomized controlled clinical trial
ISSN号1387-2877
DOI10.3233/JAD-191314
通讯作者Tang, Yi(tangyi@xwhosp.org)
英文摘要Background: Amnestic mild cognitive impairment (aMCI) is often the prodromal stage of Alzheimer's disease (AD). Although previous studies have suggested that computerized cognitive training is an effective non-pharmacological intervention for aMCI, large-sample, randomized controlled studies are warranted to provide a high level of evidence. Objective: To identify the efficacy of computerized cognitive training for aMCI. Methods: This study will include 260 patients diagnosed with aMCI from 8 centers in China. A computerized multi-domain adaptive training program will be used in this study, and the targeted cognitive domains include memory, attention, language, and executive function. The patients will be randomized into either a cognitive-training group or an active-control group. The intervention is a 12-week internet-based cognitive training performed for 40 minutes per day, 4 days a week. Neuropsychological assessments and structural and functional MRI will be obtained at baseline, at the end of the intervention, and 6 months after randomization. The primary outcome will be the global cognitive function score assessed by Montreal Cognitive Assessment. The secondary outcomes include changes in other neuropsychological assessments and neuroplasticity changes measured by structural and functional MRI. Results: The trial is currently ongoing, and it is anticipated that recruitment will be completed in December 2020. Conclusion: This multi-center, large-sample, randomized controlled trial will investigate the short and long-term effects of computerized cognitive training in patients with aMCI. Furthermore, the combination of functional and structural MRI results will also reveal the underlying mechanisms of the effect of intervention.
WOS关键词DEMENTIA ; PREVALENCE ; SHANGHAI ; SCALE
资助项目National Key R&D Program of China[2017YFC1310102] ; National Key R&D Program of China[2019YFC0118200] ; National Natural Science Foundation of China[81671040] ; National Natural Science Foundation of China[81970996] ; National Natural Science Foundation of China[81701044] ; Beijing Natural Science Foundation[JQ19024]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000541120800009
出版者IOS PRESS
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/39909]  
专题自动化研究所_脑网络组研究中心
通讯作者Tang, Yi
作者单位1.Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Innovat Ctr Neurol Disorders,Dept Neurol, Beijing, Peoples R China
2.Minist Educ Peoples Republ China, Key Lab Neurodegenerat Dis, Beijing, Peoples R China
3.Jiangsu Normal Univ, Collaborat Innovat Ctr Language Abil, Xuzhou, Jiangsu, Peoples R China
4.Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China
5.Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan, Peoples R China
6.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurol, Xian, Peoples R China
7.First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China
8.First Hosp Jilin Univ, Neurosci Ctr, Changchun, Peoples R China
9.Shanxi Med Univ, Hosp 1, Dept Neurol, Taiyuan, Peoples R China
10.Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Xing, Yi,Zhu, Zude,Du, Yifeng,et al. The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial[J]. JOURNAL OF ALZHEIMERS DISEASE,2020,75(3):779-787.
APA Xing, Yi.,Zhu, Zude.,Du, Yifeng.,Zhang, Junjian.,Qu, Qiumin.,...&Tang, Yi.(2020).The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial.JOURNAL OF ALZHEIMERS DISEASE,75(3),779-787.
MLA Xing, Yi,et al."The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial".JOURNAL OF ALZHEIMERS DISEASE 75.3(2020):779-787.

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来源：自动化研究所

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