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Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population

文献类型：期刊论文

作者Yang, Yongfeng9,10,11; Zhang, Luwen9,10,11; Guo, Dong9,10,11; Zhang, Lin8; Yu, Hongyan11; Liu, Qing9,10,11; Su, Xi9,10,11; Shao, Minglong9,10,11; Song, Men9,10,11; Zhang, Yan9,10,11
刊名FRONTIERS IN PSYCHIATRY
出版日期2020-05-25
卷号11页码:9
ISSN号1664-0640
关键词schizophrenia DTNBP1 polymorphism psychotic symptoms cognition
DOI10.3389/fpsyt.2020.00446
通讯作者Yang, Ge(yangge19800804@163.com) ; Lv, Luxian(lvx928@126.com)
英文摘要Objectives Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations inDTNBP1confer susceptibility to SZ and clinical symptoms. Here, we performed a two-stage independent verification study to identify polymorphisms of theDTNBP1gene that might be associated with SZ in the Han Chinese population. Methods In stage 1, 14 single nucleotide polymorphisms (SNPs) were genotyped in 528 paranoid SZ patients and 528 healthy controls (HCs) using the Illumina GoldenGate assays on a BeadStation 500G Genotyping System. In stage 2, ten SNPs were genotyped in an independent sample of 1,031 SZ patients and 621 HCs using the Illumina 660k Genotyping System. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale. Results There was a significant association related to allele frequency, and a trend association in relation to genotype between SZ patients and HCs at rs4712253 (p= 0.03 and 0.05, respectively). These associations were not evident following Bonferroni correction (p >0.05 for both). Haplotype association analysis revealed that only two haplotypes (GAG and GAA; rs16876575-rs9464793-rs4712253) were significantly different between SZ patients and HCs (chi(2)= 4.24, 6.37,p= 0.04 and 0.01, respectively). In addition, in SZ patients there was a significant association in the rs4964793 genotype for positive symptoms, and in the rs1011313 genotype for excitement/hostility symptoms (p= 0.01 and 0.002, respectively). We found a significant association in the baseline symbol digital modalities test (SDMT), forward-digital span (DS), backward-DS, and semantic fluency between SZ patients and HCs (p <0.05 for all). Finally, the SNP rs1011313 genotypes were associated with SDMT in SZ patients (p= 0.04). Conclusion This study provides further evidence that SNP rs4712253 ofDTNBP1has a nominal association with SZ in the Han Chinese population. Such a genotype variation may play a role in psychopathology and cognitive function.
WOS关键词GENE DTNBP1 ; DYSBINDIN ; LOCUS ; HAPLOTYPE ; VARIANTS ; BRAIN ; RISK
资助项目National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81971252] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical science and technology research project of Henan Province[2018020373] ; Science and Technology Project of Henan Province[192102310086] ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000543203500001
资助机构National Natural Science Foundation of China ; High Scientific and Technological Research Fund of Xinxiang Medical University ; National Key Research and Development Program of China ; Medical science and technology research project of Henan Province ; Science and Technology Project of Henan Province ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
源URL[http://ir.ia.ac.cn/handle/173211/39936]  
专题自动化研究所_脑网络组研究中心
通讯作者Yang, Ge; Lv, Luxian
作者单位1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Massachusetts, Med Sch, Psychiat Dept, Worcester, MA 01605 USA
4.UMass Mem Med Ctr, Worcester, MA USA
5.Henan Prov Peoples Hosp, Psychiat Dept, Zhengzhou, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
8.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China
9.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Psychiat Dept, Tongji Med Coll, Wuhan, Peoples R China
10.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yongfeng,Zhang, Luwen,Guo, Dong,et al. Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA Yang, Yongfeng.,Zhang, Luwen.,Guo, Dong.,Zhang, Lin.,Yu, Hongyan.,...&Lv, Luxian.(2020).Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population.FRONTIERS IN PSYCHIATRY,11,9.
MLA Yang, Yongfeng,et al."Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population".FRONTIERS IN PSYCHIATRY 11(2020):9.

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