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Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder

文献类型：期刊论文

作者Wang, Shengpei2,9,10; Wen, Hongwei3,8; Hu, Xiaopeng4; Xie, Peng5,6,7; Qiu, Shuang9,10; Qian, Yinfeng4; Qiu, Jiang3,8; He, Huiguang1,2,9,10
刊名MOLECULAR NEUROBIOLOGY
出版日期2020-07-10
页码14
关键词Resting-state fMRI Major depressive disorder (MDD) Hidden Markov model (HMM) Brain network dynamic Transition probability
ISSN号0893-7648
DOI10.1007/s12035-020-01995-2
通讯作者Qiu, Jiang(qiuj318@swu.edu.cn) ; He, Huiguang(huiguang.he@ia.ac.cn)
英文摘要Major depressive disorder (MDD) has been characterized by abnormal brain activity and interactions across the whole-brain functional networks. However, the underlying alteration of brain dynamics remains unclear. Here, we aim to investigate in detail the temporal dynamics of brain activity for MDD, and to characterize the spatiotemporal specificity of whole-brain networks and transitions across them. We developed a hidden Markov model (HMM) analysis for resting-state functional magnetic resonance imaging (fMRI) from two independent cohorts with MDD. In particular, one cohort included 127 MDD patients and 117 gender- and age-matched healthy controls, and the other included 44 MDD patients and 33 controls. We identified brain states characterized by the engagement of distinct functional networks that recurred over time and assessed the dynamical configuration of whole-brain networks and the patterns of activation of states that characterized the MDD groups. Furthermore, we analyzed the community structure of transitions across states to investigate the specificity and abnormality of transitions for MDD. Based on our identification of 12 HMM states, we found that the temporal reconfiguration of states in MDD was associated with the high-order cognition network (DMN), subcortical network (SUB), and sensory and motor networks (SMN). Further, we found that the specific module of transitions was closely related to MDD, which were characterized by two HMM states with opposite activations in DMN, SMN, and subcortical areas. Notably, our results provide novel insights into the dynamical circuit configuration of whole-brain networks for MDD and suggest that brain dynamics should remain a prime target for further MDD research.
WOS关键词DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; COGNITIVE DYSFUNCTION ; WHITE-MATTER ; FLUCTUATIONS ; STATES ; MRI
资助项目National Natural Science Foundation of China[:61976209] ; National Natural Science Foundation of China[61906188] ; National Natural Science Foundation of China[81701785] ; International Collaboration Key Project of Chinese Academy of Sciences (CAS)[173211KYSB20190024] ; Fundamental Research Funds fotr the Central Universities[SWU118065] ; Strategic Priority Research Program of CAS[XDB32040000]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000547222000001
出版者SPRINGER
资助机构National Natural Science Foundation of China ; International Collaboration Key Project of Chinese Academy of Sciences (CAS) ; Fundamental Research Funds fotr the Central Universities ; Strategic Priority Research Program of CAS
源URL[http://ir.ia.ac.cn/handle/173211/40099]  
专题类脑智能研究中心_神经计算及脑机交互
通讯作者Qiu, Jiang; He, Huiguang
作者单位1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
4.Anhui Med Univ, Dept Radiol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
5.Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China
6.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
7.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China
8.Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
9.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing, Peoples R China
10.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shengpei,Wen, Hongwei,Hu, Xiaopeng,et al. Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder[J]. MOLECULAR NEUROBIOLOGY,2020:14.
APA Wang, Shengpei.,Wen, Hongwei.,Hu, Xiaopeng.,Xie, Peng.,Qiu, Shuang.,...&He, Huiguang.(2020).Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder.MOLECULAR NEUROBIOLOGY,14.
MLA Wang, Shengpei,et al."Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder".MOLECULAR NEUROBIOLOGY (2020):14.

入库方式： OAI收割

来源：自动化研究所

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