Behaviors of Glioblastoma Cells in in Vitro Microenvironments
文献类型：期刊论文
| 作者 | Diao, WW; Tong, XZ; Yang, C2,4; Zhang, FR; Bao, C3,7,8; Chen, H3,7,8; Liu, LY; Li, M2,4 ; Ye, FF; Fan, QH
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019 |
| 卷号 | 9页码:85 |
| 关键词 | MATRIX GLIOMA MIGRATION BRAIN MORPHOGENESIS INCREASE GROWTH CANCER |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-36347-7 |
| 英文摘要 | Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, migration, and invasion, some of which were rarely observed before. Furthermore, how the cells invaded into the surrounding ECM and the corresponding specific invasion patterns were observed in details, implying that the four types of cells have different features during their development in cancer. This complex in vitro model, if applied to patient derived cells, possesses the potential of becoming a clinically relevant predictive model. |
| 学科主题 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/23509]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Phys Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Phys, CAS Key Lab Soft Matter Phys, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China 5.Chongqing Univ, Coll Phys, Chongqing 401331, Peoples R China 6.Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Peoples R China 7.Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou 325027, Peoples R China 8.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Peoples R China 9.Chinese Acad Sci, Inst Theoret Phys, Key Lab Theoret Phys, 55 East Zhongguancun Rd, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Diao, WW,Tong, XZ,Yang, C,et al. Behaviors of Glioblastoma Cells in in Vitro Microenvironments[J]. SCIENTIFIC REPORTS,2019,9:85. |
| APA | Diao, WW.,Tong, XZ.,Yang, C.,Zhang, FR.,Bao, C.,...&Ou-Yang, ZC.(2019).Behaviors of Glioblastoma Cells in in Vitro Microenvironments.SCIENTIFIC REPORTS,9,85. |
| MLA | Diao, WW,et al."Behaviors of Glioblastoma Cells in in Vitro Microenvironments".SCIENTIFIC REPORTS 9(2019):85. |
入库方式： OAI收割
来源：理论物理研究所
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