Template-specific fidelity of DNA replication with high-order neighbor effects: A first-passage approach
文献类型：期刊论文
| 作者 | Li, Qiu-Shi; Zheng, Pei-Dong; Shu, Yao-Gen; Ou-Yang, Zhong-Can ; Li, Ming3
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| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2019 |
| 卷号 | 100期号:1页码:12131 |
| 关键词 | MECHANISM ENZYME |
| ISSN号 | 2470-0045 |
| DOI | 10.1103/PhysRevE.100.012131 |
| 英文摘要 | DNA replication fidelity is a critical issue in molecular biology. Biochemical experiments have provided key insights on the mechanism of fidelity control by DNA polymerases in the past decades, whereas systematic theoretical studies on this issue began only recently. Because of the underlying difficulties of mathematical treatment, comprehensive surveys on the template-specific replication kinetics are still rare. Here we propose a first-passage approach to address this problem, in particular the positional fidelity, for complicated processes with high-order neighbor effects. Under biologically relevant conditions, we derived approximate analytical expressions of the positional fidelity which show intuitively how some key kinetic pathways are coordinated to guarantee the high fidelity, as well as the high velocity, of the replication processes. It is also shown that the fidelity at any template position is dominantly determined by the nearest-neighbor template sequences, which is consistent with the idea that replication mutations are randomly distributed in the genome. |
| 学科主题 | Physics |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/27102]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 作者单位 | 1.[Shu, Yao-Gen 2.[Li, Qiu-Shi 3.Zheng, Pei-Dong 4.Univ Chinese Acad Sci, Sch Phys Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Theoret Phys, Zhong Guan Cun East St 55,POB 2735, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiu-Shi,Zheng, Pei-Dong,Shu, Yao-Gen,et al. Template-specific fidelity of DNA replication with high-order neighbor effects: A first-passage approach[J]. PHYSICAL REVIEW E,2019,100(1):12131. |
| APA | Li, Qiu-Shi,Zheng, Pei-Dong,Shu, Yao-Gen,Ou-Yang, Zhong-Can,&Li, Ming.(2019).Template-specific fidelity of DNA replication with high-order neighbor effects: A first-passage approach.PHYSICAL REVIEW E,100(1),12131. |
| MLA | Li, Qiu-Shi,et al."Template-specific fidelity of DNA replication with high-order neighbor effects: A first-passage approach".PHYSICAL REVIEW E 100.1(2019):12131. |
入库方式： OAI收割
来源：理论物理研究所
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