Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
文献类型：期刊论文
| 作者 | Shaker, Sharpkate; Sang, Jun; Yan, Xue-Long; Fan, Run-Zhu; Tang, Gui-Hua; Xu, You-Kai ; Yin, Sheng5
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 176页码:- |
| 关键词 | INGOL LATEX ESTERS PLANTS |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2020.112395 |
| 英文摘要 | Eight previously undescribed diterpenoids, euphoroyleans A - H, including two cembranes, three ingenanes, two ent-atisanes, and one ent-kaurane, along with 22 known analogues were isolated from the whole plants of Euphorbia royleana. The structures of euphoroyleans A - H, including the absolute configurations, were elucidated by extensive spectroscopic analyses, chemical transformation, and single crystal X-ray diffractions. All the isolates were screened for their chemoreversal abilities on P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) cancer cell line HepG2/DOX, and eight compounds exhibited significant activities. Among them, ingol-3,7,12-triacetate-8-benzoate, the most active MDR modulator with no obvious cytotoxicity, could enhance the efficacy of anticancer drug DOX to ca. 105 folds at 10 mu M, being stronger than the positive drug verapamil. Mechanistic study revealed that ingol-3,7,12-triacetate-8-benzoate could inhibit the transport activity of P-gp rather than its expression, and the possible recognition mechanism between compounds and P-gp was predicted by molecular docking. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000542646300017 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/11751]  |
| 专题 | 西双版纳热带植物园_2012年后新成立研究组 |
| 作者单位 | 1.[Shaker, Sharpkate 2.Sang, Jun 3.Yan, Xue-Long 4.Fan, Run-Zhu 5.Tang, Gui-Hua 6.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China 7.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shaker, Sharpkate,Sang, Jun,Yan, Xue-Long,et al. Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells[J]. PHYTOCHEMISTRY,2020,176:-. |
| APA | Shaker, Sharpkate.,Sang, Jun.,Yan, Xue-Long.,Fan, Run-Zhu.,Tang, Gui-Hua.,...&Yin, Sheng.(2020).Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells.PHYTOCHEMISTRY,176,-. |
| MLA | Shaker, Sharpkate,et al."Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells".PHYTOCHEMISTRY 176(2020):-. |
入库方式： OAI收割
来源：西双版纳热带植物园
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