A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein
文献类型:期刊论文
作者 | Zhou, Hong; Chen, Xing; Hu, Tao; Li, Juan; Song, Hao2; Liu, Yanran; Wang, Peihan; Liu, Di3; Yang, Jing4; Holmes, Edward C. |
刊名 | CURRENT BIOLOGY |
出版日期 | 2020 |
卷号 | 30期号:11页码:2196-+ |
ISSN号 | 0960-9822 |
关键词 | RECEPTOR-BINDING DOMAIN AVIAN INFLUENZA-VIRUS ORIGIN |
DOI | 10.1016/j.cub.2020.05.023 |
英文摘要 | The unprecedented pandemic of pneumonia caused by a novel coronavirus, SARS-CoV-2, in China and beyond has had major public health impacts on a global scale [1, 2]. Although bats are regarded as the most likely natural hosts for SARS-CoV-2 [3], the origins of the virus remain unclear. Here, we report a novel bat-derived coronavirus, denoted RmYN02, identified from a metagenomic analysis of samples from 227 bats collected from Yunnan Province in China between May and October 2019. Notably, RmYN02 shares 93.3% nucleotide identity with SARS-CoV-2 at the scale of the complete virus genome and 97.2% identity in the 1ab gene, in which it is the closest relative of SARS-CoV-2 reported to date. In contrast, RmYN02 showed low sequence identity (61.3%) to SARS-CoV-2 in the receptor-binding domain (RBD) and might not bind to angiotensin-converting enzyme 2 (ACE2). Critically, and in a similar manner to SARS-CoV-2, RmYN02 was characterized by the insertion of multiple amino acids at the junction site of the S1 and S2 subunits of the spike (S) protein. This provides strong evidence that such insertion events can occur naturally in animal betacoronaviruses. |
学科主题 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000538803300040 |
源URL | [http://ir.xtbg.org.cn/handle/353005/11766] |
专题 | 西双版纳热带植物园_2012年后新成立研究组 |
作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An 271000, Shandong, Peoples R China 2.Chen, Xing; Hughes, Alice C.] Chinese Acad Sci, Ctr Integrat Conservat, Landscape Ecol Grp, Xishuangbanna Trop Bot Garden, Mengla 666303, Yunnan, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RNIH, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Ctr Bacteria & Virus Resources & Bioinformat, Wuhan Inst Virol, Computat Virol Grp, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, TWAS Ctr Excellence Emerging Infect Dis CEEID, Inst Microbiol,Key Lab Pathogen Microbiol & Immun, Beijing 100101, Peoples R China 6.Holmes, Edward C.] Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia 7.Holmes, Edward C.] Univ Sydney, Sch Med Sci, Sydney, NSW 2006, Australia 8.Shandong First Med Univ, Shandong Prov Qianfoshan Hosp, Affiliated Hosp 1, Jinan 250014, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Hong,Chen, Xing,Hu, Tao,et al. A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein[J]. CURRENT BIOLOGY,2020,30(11):2196-+. |
APA | Zhou, Hong.,Chen, Xing.,Hu, Tao.,Li, Juan.,Song, Hao.,...&Shi, Weifeng.(2020).A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein.CURRENT BIOLOGY,30(11),2196-+. |
MLA | Zhou, Hong,et al."A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein".CURRENT BIOLOGY 30.11(2020):2196-+. |
入库方式: OAI收割
来源:西双版纳热带植物园
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