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Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone

文献类型：期刊论文

作者Guo, Chunyang1,2; Zhang, Qi3; Zhu, Bingqing3; Zhang, Zaiyong3; Ma, Xiaoyu3,4; Dai, Wenjuan3; Gong, Xiaoyi3; Ren, Guobin1,2; Mei, Xuefeng3
刊名CRYSTAL GROWTH & DESIGN
出版日期2020-05-06
卷号20期号:5页码:3053-3063
ISSN号1528-7483
DOI10.1021/acs.cgd.9b01688
通讯作者Ren, Guobin(rgb@ecust.edu.cn) ; Mei, Xuefeng(xuefengmei@simm.ac.cn)
英文摘要Progesterone (Prog), a natural steroid hormone, is widely used in birth control pills and menopausal hormone replacement therapies. Phloroglucinol (SPF) and resveratrol (RSV) are also two kinds of active products that can be used during pregnancy. Drug-drug cocrystals of Prog with SPF and RSV were designed and successfully synthesized for purpose of bringing improvements of drug properties, including solubility, hydroscopic stability, and color stability. The cocrystals and their hydrate structures were systematically characterized by X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. In addition, powder dissolution experiments of Prog, Prog-SPF, and Prog-RSV were conducted in aqueous solutions with the presence of different surfactants, and the result revealed that the Prog-SPF cocrystal exhibits a superior solubility compared with Prog and Prog-RSV. Furthermore, the Prog-SPF cocrystal also enhances the hydroscopic stability and color stability of SPF. Those findings may provide a promising formulation to overcome some weaknesses of the parent drugs.
WOS关键词SOLID-STATE CHARACTERIZATION ; PHARMACEUTICAL COCRYSTALS ; RESVERATROL SUPPLEMENTATION ; SOLUBILITY ; PHLOROGLUCINOL ; CRYSTALS ; PREGNENOLONE ; PERMEABILITY ; OPPORTUNITY ; FORMULATION
资助项目National Natural Science Foundation of China[21576080] ; National Natural Science Foundation of China[21776073] ; Shanghai Natural Science Foundation[18ZR1447900] ; Youth Innovation Promotion Association of CAS[2016257] ; CAS Key Technology Talent Program ; SANOFI-SIBS Scholarship
WOS研究方向Chemistry ; Crystallography ; Materials Science
语种英语
WOS记录号WOS:000535174000027
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/280020]  
专题中国科学院上海药物研究所
通讯作者Ren, Guobin; Mei, Xuefeng
作者单位1.East China Univ Sci & Technol, Lab Pharmaceut Crystal Engn & Technol, Sch Pharm, Shanghai 200237, Peoples R China
2.East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Chunyang,Zhang, Qi,Zhu, Bingqing,et al. Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone[J]. CRYSTAL GROWTH & DESIGN,2020,20(5):3053-3063.
APA Guo, Chunyang.,Zhang, Qi.,Zhu, Bingqing.,Zhang, Zaiyong.,Ma, Xiaoyu.,...&Mei, Xuefeng.(2020).Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone.CRYSTAL GROWTH & DESIGN,20(5),3053-3063.
MLA Guo, Chunyang,et al."Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone".CRYSTAL GROWTH & DESIGN 20.5(2020):3053-3063.

入库方式： OAI收割

来源：上海药物研究所

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